Hisham El-Masri
Overview
Explore the profile of Hisham El-Masri including associated specialties, affiliations and a list of published articles.
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23
Citations
169
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Recent Articles
1.
Decrane R, Stoker T, Murr A, Ford J, El-Masri H
Curr Res Toxicol
. 2023 Dec;
5:100138.
PMID: 38074188
The thyroid hormones play key roles in physiological processes such as regulation of the metabolic and cardiac systems as well as the development of the brain and surrounding sympathetic nervous...
2.
Douillet C, Miller M, Cable P, Shi Q, El-Masri H, Matousek T, et al.
Sci Rep
. 2023 Mar;
13(1):3660.
PMID: 36871058
Although mice are widely used to study adverse effects of inorganic arsenic (iAs), higher rates of iAs methylation in mice than in humans may limit their utility as a model...
3.
El-Masri H, Paul Friedman K, Isaacs K, Wetmore B
Toxicol Appl Pharmacol
. 2022 Jul;
450:116141.
PMID: 35777528
Human health risk assessment is a function of chemical toxicity, bioavailability to reach target biological tissues, and potential environmental exposure. These factors are complicated by many physiological, biochemical, physical and...
4.
Handa S, Hassan I, Gilbert M, El-Masri H
Toxicol Sci
. 2021 Jun;
183(1):36-48.
PMID: 34117770
High-throughput in vitro assays are developed to screen chemicals for their potential to inhibit thyroid hormones (THs) synthesis. Some of these experiments, such as the thyroid peroxidase (TPO) inhibition assay,...
5.
Thresholds Derived From Common Measures in Rat Studies Are Predictive of Liver Tumorigenic Chemicals
Corton J, Korunes K, Abedini J, El-Masri H, Brown J, Paul-Friedman K, et al.
Toxicol Pathol
. 2020 Oct;
48(7):857-874.
PMID: 33084515
We hypothesized that typical tissue and clinical chemistry (ClinChem) end points measured in rat toxicity studies exhibit chemical-independent biological thresholds beyond which cancer occurs. Using the rat in vivo TG-GATES...
6.
Koller B, Snouwaert J, Douillet C, Jania L, El-Masri H, Thomas D, et al.
Environ Health Perspect
. 2020 Aug;
128(8):87003.
PMID: 32779937
Background: Chronic exposure to inorganic arsenic (iAs) is a significant public health problem. Methylation of iAs by arsenic methyltransferase (AS3MT) controls iAs detoxification and modifies risks of iAs-induced diseases. Mechanisms...
7.
Hill T, Rooney J, Abedini J, El-Masri H, Wood C, Corton J
Toxicol Sci
. 2020 Jul;
177(1):41-59.
PMID: 32603419
Traditional methods for cancer risk assessment are resource-intensive, retrospective, and not feasible for the vast majority of environmental chemicals. In this study, we investigated whether quantitative genomic data from short-term...
8.
Hassan I, El-Masri H, Ford J, Brennan A, Handa S, Paul Friedman K, et al.
Toxicol Sci
. 2019 Nov;
173(2):280-292.
PMID: 31697382
Thyroperoxidase (TPO) is an enzyme essential for thyroid hormone (TH) synthesis and a target site for a number of xenobiotics that disrupt TH homeostasis. An in vitro high-throughput screening assay...
9.
Abedini J, Handa S, Edwards S, Chorley B, El-Masri H
Toxicol Appl Pharmacol
. 2019 Sep;
382:114757.
PMID: 31520653
A range of chemical exposures that resulted in the specific pathology of hepatic lipid dysfunction in rats were selected from DrugMatrix, a publicly available toxicogenomic database. Raw microarray data collected...
10.
Cohen Hubal E, Wetmore B, Wambaugh J, El-Masri H, Sobus J, Bahadori T
J Expo Sci Environ Epidemiol
. 2018 Aug;
29(1):11-20.
PMID: 30116055
Scientifically sound, risk-informed evaluation of chemicals is essential to protecting public health. Systematically leveraging information from exposure, toxicology, and epidemiology studies can provide a holistic understanding of how real-world exposure...