Hisham Bazzi
Overview
Explore the profile of Hisham Bazzi including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
1016
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Recent Articles
1.
Boix J, Knuever J, Niehoff N, Sen A, Pla-Martin D, Baris O, et al.
J Invest Dermatol
. 2024 Nov;
PMID: 39580109
Epidermis is one of the most rapidly proliferating tissues in the body with high demands for adenosine triphosphate and cellular building blocks. In this study, we show that to meet...
2.
Meyer-Gerards C, Bazzi H
FEBS J
. 2024 Jun;
292(4):709-726.
PMID: 38935637
Centrosomes are dominant microtubule organizing centers in animal cells with a pair of centrioles at their core. They template cilia during interphase and help organize the mitotic spindle for a...
3.
Grzonka M, Bazzi H
Elife
. 2024 Feb;
13.
PMID: 38407237
SAS-6 (SASS6) is essential for centriole formation in human cells and other organisms but its functions in the mouse are unclear. Here, we report that -mutant mouse embryos lack centrioles,...
4.
Camblor-Perujo S, Ozer Yildiz E, Kupper H, Overhoff M, Rastogi S, Bazzi H, et al.
Life Sci Alliance
. 2023 Dec;
7(2).
PMID: 38086550
Centrosomes are organelles that nucleate microtubules via the activity of gamma-tubulin ring complexes (γ-TuRC). In the developing brain, centrosome integrity is central to the progression of the neural progenitor cell...
5.
Khatif H, Bazzi H
Genesis
. 2023 Jul;
62(1):e23532.
PMID: 37435631
Ectodermal appendages in mammals, such as teeth, mammary glands, sweat glands and hair follicles, are generated during embryogenesis through a series of mesenchymal-epithelial interactions. Canonical Wnt signaling and its inhibitors...
6.
Bartsch D, Kalamkar K, Ahuja G, Lackmann J, Hescheler J, Weber T, et al.
Sci Adv
. 2023 Mar;
9(13):eade1792.
PMID: 36989351
The blueprints of developing organs are preset at the early stages of embryogenesis. Transcriptional and epigenetic mechanisms are proposed to preset developmental trajectories. However, we reveal that the competence for...
7.
Crispatzu G, Rehimi R, Pachano T, Bleckwehl T, Cruz-Molina S, Xiao C, et al.
Nat Commun
. 2021 Jul;
12(1):4344.
PMID: 34272393
Poised enhancers (PEs) represent a genetically distinct set of distal regulatory elements that control the expression of major developmental genes. Before becoming activated in differentiating cells, PEs are already bookmarked...
8.
Damen M, Wirtz L, Soroka E, Khatif H, Kukat C, Simons B, et al.
Nat Commun
. 2021 May;
12(1):3227.
PMID: 34050161
The development of complex stratified epithelial barriers in mammals is initiated from single-layered epithelia. How stratification is initiated and fueled are still open questions. Previous studies on skin epidermal stratification...
9.
Xiao C, Grzonka M, Meyer-Gerards C, Mack M, Figge R, Bazzi H
EMBO Rep
. 2021 Jan;
22(2):e51127.
PMID: 33410253
Centrosomes, composed of two centrioles and pericentriolar material, organize mitotic spindles during cell division and template cilia during interphase. The first few divisions during mouse development occur without centrioles, which...
10.
Phan T, Maryniak A, Boatwright C, Lee J, Atkins A, Tijhuis A, et al.
EMBO J
. 2020 Nov;
40(1):e106118.
PMID: 33226141
Mutations in centrosome genes deplete neural progenitor cells (NPCs) during brain development, causing microcephaly. While NPC attrition is linked to TP53-mediated cell death in several microcephaly models, how TP53 is...