Hisao Nagaya
Overview
Explore the profile of Hisao Nagaya including associated specialties, affiliations and a list of published articles.
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24
Citations
415
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Recent Articles
1.
Niwa M, Arakawa T, Arai K, Koyama N, Hara H, Hata K, et al.
Bioanalysis
. 2024 Sep;
16(19-20):1005-1010.
PMID: 39263699
The 15th Japan Bioanalysis Forum (JBF) Symposium was held in Kyoto, Japan, between 5 and 7 February 2024. The conference theme, 'Toward the new world - Science as a universal...
2.
Nakagawa Y, Nagaya H, Miyata T, Wada Y, Oyama T, Gotoh A
Anticancer Res
. 2016 Apr;
36(4):1563-70.
PMID: 27069132
A retrospective observational cohort study has shown that exposure to alpha-1 adrenergic receptor (AR) blocker reduces the risk of bladder cancer (BCa). We investigated the antitumor activity of alpha-1 blockers,...
3.
Tsuchiya A, Nagaya H, Kanno T, Nishizaki T
J Pharmacol Sci
. 2014 Nov;
126(4):337-43.
PMID: 25391857
The present study investigated cis-unsaturated free fatty acid (FFA)-regulated glucose uptake. In the cell-free assay of protein tyrosine phosphatase 1B (PTP1B), cis-unsaturated FFAs such as linoleic, linolenic, and oleic acid...
4.
Mikami K, Nagaya H, Gotoh A, Kanno T, Tsuchiya A, Nakano T, et al.
Pharmacology
. 2014 Oct;
94(3-4):163-9.
PMID: 25301502
Naftopidil, an α1-adrenoceptor blocker, induced apoptosis of human malignant pleural mesothelioma NCI-H2052 cells. Naftopidil upregulated the expression of tumor necrosis factor-α (TNF-α) mRNA in these cells. Naftopidil, alternatively, increased FasL...
5.
Kaku Y, Nagaya H, Tsuchiya A, Kanno T, Gotoh A, Tanaka A, et al.
Cancer Sci
. 2014 Apr;
105(7):883-9.
PMID: 24754309
The newly synthesized naftopidil analogue HUHS1015 reduced cell viability in malignant pleural mesothelioma cell lines MSTO-211H, NCI-H28, NCI-H2052, and NCI-H2452, with the potential greater than that for the anticancer drugs...
6.
Tsuchiya A, Kanno T, Nagaya H, Shimizu T, Tanaka A, Nishizaki T
Cell Physiol Biochem
. 2014 Apr;
33(4):1097-105.
PMID: 24732916
Background/aims: The present study investigated the signaling pathway underlying Rac1 activation induced by the linoleic acid derivative 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA). Methods: Activity of protein tyrosine phosphatase 1B (PTP1B) was assayed...
7.
Yuasa T, Amo K, Ishikura S, Nagaya H, Uchiyama K, Hashida S, et al.
Biochem Biophys Res Commun
. 2014 Feb;
445(1):236-43.
PMID: 24508798
Soluble insulin receptor (sIR), the ectodomain of IR, has been detected in human plasma, and its concentration parallels that of blood glucose in patients with diabetes. IR has a pivotal...
8.
Tamura T, Arai S, Nagaya H, Mizuguchi J, Wada I
PLoS One
. 2013 Sep;
8(9):e74580.
PMID: 24040290
The endoplasmic reticulum (ER) plays essential roles in protein folding and assembly of secretory proteins. ER-resident molecular chaperones and related enzymes assist in protein maturation by co-operated interactions and modifications....
9.
Niba E, Nagaya H, Kanno T, Tsuchiya A, Gotoh A, Tabata C, et al.
Cell Physiol Biochem
. 2013 Jul;
31(6):905-13.
PMID: 23817184
Background/aims: Our earlier studies suggested crosstalk between IRS/PI3 kinase/PDK1/Akt/Rac1/ROCK and (Shc2/Grb2/SOS)/Ras/Raf/MEK/ERK pathways downstream PDGF-ββ receptor responsible for chemotaxis and proliferation of malignant mesothelioma cells. The present study was conducted to...
10.
Gotoh A, Nagaya H, Kanno T, Tagawa M, Nishizaki T
Urology
. 2013 Feb;
81(4):920.e7-11.
PMID: 23394881
Objective: To assess the oncolytic effect of fiber-substituted conditionally replicating adenovirus type 5 (Ad5) F35 vector on human bladder cancer cell lines such as 253J, 5637, KK-47, T24, TCCSUP, and...