Hirotatsu Kojima
Overview
Explore the profile of Hirotatsu Kojima including associated specialties, affiliations and a list of published articles.
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Articles
108
Citations
1824
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Recent Articles
1.
Sawayama R, Minoda M, Kojima H, Okabe T, Isayama Y, Kato K, et al.
ACS Sens
. 2025 Feb;
10(2):664-670.
PMID: 39903855
We propose the design strategy of fluorogenic probes of proteases/peptidases and acylamino acid hydrolases utilizing an intramolecular O-to-N phosphoryl transfer reaction, in which the main chain of peptides or amino...
2.
Sasaki J, Sato A, Sasaki M, Okabe I, Kodama K, Otsuguro S, et al.
Antiviral Res
. 2024 Nov;
232:106039.
PMID: 39571911
Coronaviruses such as the Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and SARS-CoV-2, causing MERS, SARS, and Coronavirus disease-19, respectively, are highly pathogenic to humans....
3.
Maruyama T, Takahashi Y, Hiro K, Murase K, Kojima H, Okabe T, et al.
ACS Med Chem Lett
. 2024 Jul;
15(5):667-676.
PMID: 38994455
Sterol regulatory element-binding protein-1 (SREBP-1) is a transcription factor that regulates the expression of genes related to fatty acid biosynthesis. Its high expression and activation in obesity and associated metabolic...
4.
Hara S, Kono H, Suto N, Kojima H, Kishimoto K, Yoshino H, et al.
Biochem Biophys Res Commun
. 2024 May;
717:150059.
PMID: 38723517
Tetrahydrobiopterin (BH4) is an essential cofactor for dopamine and serotonin synthesis in monoaminergic neurons, phenylalanine metabolism in hepatocytes, and nitric oxide synthesis in endothelial and immune cells. BH4 is consumed...
5.
Shiino H, Tashiro S, Hashimoto M, Sakata Y, Hosoya T, Endo T, et al.
iScience
. 2024 Feb;
27(3):109189.
PMID: 38420588
Phospholipids are major components of biological membranes and play structural and regulatory roles in various biological processes. To determine the biological significance of phospholipids, the use of chemical inhibitors of...
6.
Mitsuishi Y, Nakano M, Kojima H, Okabe T, Nishimura M
ACS Chem Neurosci
. 2024 Feb;
15(6):1234-1241.
PMID: 38416107
Brain amyloid-β (Aβ) governs the pathogenic process of Alzheimer's disease. Clinical trials to assess the disease-modifying effects of inhibitors or modulators of β- and γ-secretases have not shown clinical benefit...
7.
Hino T, Nakahara F, Miyauchi M, Ito Y, Masamoto Y, Morita K, et al.
Exp Hematol
. 2023 Dec;
130:104137.
PMID: 38103826
Neutrophils are key components of the immune system that inhibit bacterial infections. Systemic bacterial infections can cause lethal conditions, especially in patients with neutropenia associated with chemotherapy or other systemic...
8.
Onodera K, Hasegawa Y, Yokota N, Tamura S, Kinno H, Takahashi I, et al.
Obesity (Silver Spring)
. 2023 Nov;
32(2):324-338.
PMID: 37974549
Objective: Promoting thermogenesis in adipose tissue has been a promising strategy against obesity and related metabolic complications. We aimed to identify compounds that promote thermogenesis in adipocytes and to elucidate...
9.
Echizen H, Hanaoka K, Shimamoto K, Hibi R, Toma-Fukai S, Ohno H, et al.
Sci Rep
. 2023 Sep;
13(1):16456.
PMID: 37777556
D,L-Propargylglycine (PAG) has been widely used as a selective inhibitor to investigate the biological functions of cystathionine γ-lyase (CSE), which catalyzes the formation of reactive sulfur species (RSS). However, PAG...
10.
Yanagi K, Komatsu T, Fujikawa Y, Kojima H, Okabe T, Nagano T, et al.
Commun Chem
. 2023 Apr;
6(1):68.
PMID: 37055561
Controlling tumor-specific alterations in metabolic pathways is a useful strategy for treating tumors. The glyoxalase pathway, which metabolizes the toxic electrophile 2-methylglyoxal (MG), is thought to contribute to tumor pathology....