Hironobu Tsukada
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Explore the profile of Hironobu Tsukada including associated specialties, affiliations and a list of published articles.
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8
Citations
98
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Recent Articles
1.
Xiao G, Tsukada H, Chen Y, Shi L, Hopkins S, Galluppi G
Pharmacol Res Perspect
. 2024 Mar;
12(2):e1191.
PMID: 38527949
Ulotaront (SEP-363856) is a TAAR1 agonist, with 5-HT1A agonist activity, currently in clinical development for the treatment of schizophrenia. In vitro studies indicate ulotaront is an OCT2-specific inhibitor with IC...
2.
Tsukada H, Chen Y, Xiao G, Lennek L, Milanovic S, Worden M, et al.
Clin Pharmacokinet
. 2023 Oct;
62(12):1755-1763.
PMID: 37882999
Background: Ulotaront is a novel psychotropic agent with agonist activity at trace amine-associated receptor 1 (TAAR1) and 5-hydroxytryptamine type 1A (5-HT) receptors in phase III clinical development for the treatment...
3.
Tsukada H, Milanovic S, Darpo B, Xue H, Xiong K, Tripp E, et al.
Clin Transl Sci
. 2023 Mar;
16(6):1063-1074.
PMID: 36949248
This study (NCT04369391) evaluated the effects of ulotaront (SEP-363856), a novel trace amine-associated receptor 1 (TAAR1) agonist in development for schizophrenia, on electrocardiogram parameters. Study design was a randomized, single-dose,...
4.
Chen Y, Tsukada H, Milanovic S, Shi L, Li Y, Mao Y, et al.
Neurol Ther
. 2023 Mar;
12(3):815-832.
PMID: 36932300
Introduction: Ulotaront (SEP-363856), a dual trace animeassociated receptor 1 (TAAR1) and 5-HT receptor agonist, is in phase 3 clinical development for the treatment of schizophrenia. This study evaluated the comparative...
5.
Tsukada H, Ochi H, Maekawa T, Abe H, Fujimoto Y, Tsuge M, et al.
Gastroenterology
. 2009 Feb;
136(5):1796-805.e6.
PMID: 19208361
Background & Aims: This study aimed to identify host single nucleotide polymorphisms (SNPs) that are associated with the efficacy of interferon (IFN) therapy in patients with chronic hepatitis C. Methods:...
6.
Tsujita T, Ishii A, Tsukada H, Matsumoto M, Che F, Seya T
Vaccine
. 2005 Nov;
24(12):2193-9.
PMID: 16314010
Fish has a soluble form of TLR5 ortholog (TLR5S), which does not exist in mammals. We identified TLR5S from rainbow trout and named rtTLR5S, which was about 38% homologous to...
7.
Tsukada H, Fukui A, Tsujita T, Matsumoto M, Iida T, Seya T
Int J Mol Med
. 2005 Feb;
15(3):519-25.
PMID: 15702248
From an EST fragment of the rainbow trout that was predicted to contain leucine-rich repeats (LRR), we cloned the whole cDNA and identified a soluble form of TLR5 ortholog (rtTLR5S),...
8.
Tsujita T, Tsukada H, Nakao M, Oshiumi H, Matsumoto M, Seya T
J Biol Chem
. 2004 Sep;
279(47):48588-97.
PMID: 15339910
Rainbow trout (Onchorhynchus mikiss) possess two genes encoding putative leucine-rich repeat (LRR)-containing proteins similar to human TLR5. Molecular cloning of these two LRR proteins suggested the presence of a TLR5-like...