Hirokazu Tsukamoto
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Explore the profile of Hirokazu Tsukamoto including associated specialties, affiliations and a list of published articles.
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34
Citations
370
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Recent Articles
1.
Tsukamoto H, Ito K, Ueno T, Shiraishi M, Kondo Y, Doi T
Chemistry
. 2023 Jan;
29(6):e202300086.
PMID: 36690588
Invited for the cover of this issue is the group of Hirokazu Tsukamoto at Tohoku University (current affiliation: Yokohama University of Pharmacy). The image depicts anti-selective arylative cyclization reactions of...
2.
Tsukamoto H, Ito K, Ueno T, Shiraishi M, Kondo Y, Doi T
Chemistry
. 2022 Nov;
29(6):e202203068.
PMID: 36333971
Palladium(0)/monophosphine complexes catalyze anti-selective alkylative, arylative, and alkynylative cyclizations of alkynyl electrophiles with organometallic reagents. The remarkable anti-selectivity results from novel oxidative addition, that is, the nucleophilic attack of electron-rich...
3.
Tsukamoto H, Nakamura S, Tomida A, Doi T
Chemistry
. 2020 Apr;
26(55):12528-12532.
PMID: 32291830
Haouamines A, B, and their derivatives were synthesized via Suzuki-Miyaura coupling and three key cyclization reactions as follows: the newly developed palladium(0)-catalyzed arylative cyclization of phenylalanine-derived alkyne-aldehydes with 2-bromoarylboronic acid...
4.
Tsukamoto H, Konno T, Ito K, Doi T
Org Lett
. 2019 Aug;
21(17):6811-6814.
PMID: 31442059
Axially chiral 1,3-disubstituted allenes were synthesized via hydroalkylation of alkyl- or aryl-substituted conjugated enynes (readily prepared via a Sonogashira reaction) with pronucleophiles such as dimethyl malonate under the cocatalysis of...
5.
Tsukamoto H, Hanada S, Nomura Y, Doi T
J Org Chem
. 2018 Jun;
83(16):9430-9441.
PMID: 29895147
Spiromamakone A is a racemic natural product having a naphthyl acetal group on a spiro[4,4]nonadiene skeleton. Its total synthesis was achieved by double oxa-Michael addition of 1,8-dihydroxynaphthalene to 2-(1-bromoalkylidene)-4-isopropoxy-4-cyclopentene-1,3-dione, which...
6.
Tsukamoto H, Nomura Y, Fujiwara K, Hanada S, Doi T
Org Lett
. 2018 May;
20(10):3140-3143.
PMID: 29737863
A conjugate addition of diverse nucleophiles to acylketene acetals derived from 1,8-dihydroxynaphthalene (DHN) is developed for the formation of its 3-oxoalkan-1-one acetals. The initial acylketene acetals are prepared via double...
7.
Tsukamoto H, Ito K, Doi T
Chem Commun (Camb)
. 2018 May;
54(40):5102-5105.
PMID: 29714394
Multi-substituted dihydrofurans were obtained from a palladium-catalysed coupling reaction between 2,3-alkadienols and ketones bearing an electron-withdrawing group at the α-position. Methanol as a solvent was essential for the initial dehydrative...
8.
Tsukamoto H, Hanada S, Kumasaka K, Kagaya N, Izumikawa M, Shin-Ya K, et al.
Org Lett
. 2016 Sep;
18(19):4848-4851.
PMID: 27648608
Two benzo analogues of cytotoxic spiromamakone A, comprising carbon atoms with the same oxidation state and unsaturation degree as those of the natural products, are synthesized and biologically evaluated. Substitution...
9.
Tsukamoto H, Ikeda T, Doi T
J Org Chem
. 2015 Nov;
81(5):1733-45.
PMID: 26603501
1,2-Bis(diphenylphosphino)ethane (dppe)-ligated palladium(II) complexes catalyze the annulation of internal alkynes with 2-(cyanomethyl)phenylboronates to provide 3,4-disubstituted-2-naphthalenamines in good yields. The annulation reaction proceeds under mild and neutral conditions and requires methanol...
10.
Tsukamoto H, Kawase A, Doi T
Chem Commun (Camb)
. 2015 Apr;
51(38):8027-30.
PMID: 25873404
Palladium/chiral diphosphine-catalyzed umpolung cyclization of allylic acetate-aldehyde using formate as a terminal reductant affords cis-disubstituted pyrrolidine, tetrahydrofuran, and spiro carbocycle in high enantioselectivity. The formate does not cause allylpalladium reduction...