Hieronim Jakubowski
Overview
Explore the profile of Hieronim Jakubowski including associated specialties, affiliations and a list of published articles.
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Articles
118
Citations
1600
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Recent Articles
1.
Jakubowski H, Witucki L
Int J Mol Sci
. 2025 Jan;
26(2).
PMID: 39859460
Atherosclerosis is accompanied by inflammation that underlies cardiovascular disease (CVD) and its vascular manifestations, including acute stroke, myocardial infarction, and peripheral artery disease, the leading causes of morbidity/mortality worldwide. The...
2.
Jakubowski H
Antioxidants (Basel)
. 2024 Nov;
13(11).
PMID: 39594433
The anti-oxidative and anti-inflammatory properties of high-density lipoprotein (HDL) are thought to be mediated by paraoxonase 1 (PON1), a calcium-dependent hydrolytic enzyme carried on a subfraction of HDL that also...
3.
Witucki L, Jakubowski H
FASEB J
. 2024 Sep;
38(18):e70072.
PMID: 39323294
The inability to efficiently metabolize homocysteine (Hcy) due to nutritional and genetic deficiencies, leads to hyperhomocysteinemia (HHcy) and endothelial dysfunction, a hallmark of atherosclerosis which underpins cardiovascular disease (CVD). PHF8...
4.
Utyro O, Wloczkowska-Lapinska O, Jakubowski H
J Alzheimers Dis
. 2024 Sep;
101(3):823-834.
PMID: 39302370
Background: Glyoxalase domain containing protein 4 (GLOD4), a protein of an unknown function, is associated with Alzheimer's disease (AD). Three GLOD4 isoforms are known. The mechanism underlying GLOD4's association with...
5.
Jakubowski H
Int J Mol Sci
. 2024 Aug;
25(15).
PMID: 39125665
Elevated levels of homocysteine (Hcy) and related metabolites are associated with Alzheimer's disease (AD). Severe hyperhomocysteinemia causes neurological deficits and worsens behavioral and biochemical traits associated with AD. Although Hcy...
6.
Jakubowski H, Sikora M, Bretes E, Perla-Kajan J, Utyro O, Wojtasz I, et al.
Life (Basel)
. 2024 May;
14(5).
PMID: 38792655
Objectives-Metallic elements and fibrin clot properties have been linked to stroke. We examined metallic and nonmetallic elements, fibrin clot lysis time (CLT), and maximum absorbance (Abs) in relation to ischemic...
7.
Sikora M, Bretes E, Perla-Kajan J, Utyro O, Borowczyk K, Piechocka J, et al.
Sci Rep
. 2024 May;
14(1):11222.
PMID: 38755170
Homocysteine (Hcy) and Hcy-thiolactone (HTL) affect fibrin clot properties and are linked to cardiovascular disease. Factors that influence fibrin clot properties and stroke are not fully understood. To study sulfur-containing...
8.
Suszynska-Zajczyk J, Witucki L, Perla-Kajan J, Jakubowski H
Front Cell Dev Biol
. 2024 Apr;
12:1322844.
PMID: 38559811
Hyperhomocysteinemia (HHcy), characterized by elevated homocysteine (Hcy) levels, is a known risk factor for cardiovascular, renal, and neurological diseases, as well as pregnancy complications. Our study aimed to investigate whether...
9.
Witucki L, Jakubowski H
Sci Rep
. 2024 Mar;
14(1):7151.
PMID: 38531978
Nutritional and genetic deficiencies in homocysteine (Hcy) metabolism lead to hyperhomocysteinemia (HHcy) and cause endothelial dysfunction, a hallmark of atherosclerosis, which is a major cause of cardiovascular disease (CVD). Impaired...
10.
Witucki L, Borowczyk K, Suszynska-Zajczyk J, Warzych E, Pawlak P, Jakubowski H
J Alzheimers Dis
. 2023 Sep;
95(4):1735-1755.
PMID: 37718819
Background: Bleomycin hydrolase (BLMH), a homocysteine (Hcy)-thiolactone detoxifying enzyme, is attenuated in Alzheimer's disease (AD) brains. Blmh loss causes astrogliosis in mice while the loss of histone demethylase Phf8, which...