Hideki Nishio
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Explore the profile of Hideki Nishio including associated specialties, affiliations and a list of published articles.
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74
Citations
1388
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Recent Articles
1.
Hata S, Saito H, Kakiuchi T, Fukumoto D, Yamamoto S, Kasuga K, et al.
EMBO Mol Med
. 2023 Mar;
15(5):e17052.
PMID: 36994913
We propose a new therapeutic strategy for Alzheimer's disease (AD). Brain peptide p3-Alcβ37 is generated from the neuronal protein alcadein β through cleavage of γ-secretase, similar to the generation of...
2.
Nomura K, Mori S, Fujikawa K, Osawa T, Tsuda S, Yoshizawa-Kumagaye K, et al.
Sci Rep
. 2022 Jul;
12(1):12231.
PMID: 35851412
Non-proteinaceous components in membranes regulate membrane protein insertion cooperatively with proteinaceous translocons. An endogenous glycolipid in the Escherichia coli membrane called membrane protein integrase (MPIase) is one such component. Here,...
3.
Mori S, Nomura K, Fujikawa K, Osawa T, Shionyu M, Yoda T, et al.
ACS Chem Biol
. 2022 Mar;
17(3):609-618.
PMID: 35239308
Inducing newly synthesized proteins to appropriate locations is an indispensable biological function in every organism. Integration of proteins into biomembranes in is mediated by proteinaceous factors, such as Sec translocons...
4.
Takabayashi K, Kitaguchi S, Iwatsu K, Morikami Y, Ichinohe T, Yamamoto T, et al.
J Cardiol
. 2019 Jan;
73(6):522-529.
PMID: 30598389
Background: Although activities of daily living (ADL) are recognized as being pertinent in averting relevant readmission of heart failure (HF) and mortality, little research has been conducted to assess a...
5.
Tsuda S, Nishio H, Yoshiya T
Chem Commun (Camb)
. 2018 Jul;
54(64):8861-8864.
PMID: 30039130
Canaline (Can) is a non-proteinogenic amino acid containing an aminooxy group in its side chain. Can-containing peptides can be synthesized by standard Fmoc SPPS using Fmoc-Can(2-Cl-Trt). Here, for the first...
6.
Tsuda S, Mochizuki M, Ishiba H, Yoshizawa-Kumagaye K, Nishio H, Oishi S, et al.
Angew Chem Int Ed Engl
. 2018 Jan;
57(8):2105-2109.
PMID: 29316103
A solubilizing Trt-K tag was developed for the effective chemical preparation of peptides/proteins with low solubility. The Trt-K tag comprises a hydrophilic oligo-Lys sequence and a trityl anchor, and can...
7.
Sakamoto K, Tsuda S, Nishio H, Yoshiya T
Chem Commun (Camb)
. 2017 Nov;
53(90):12236-12239.
PMID: 29086777
1,2,4-Triazole facilitated native chemical ligation (NCL) between peptide-MeNbz (MeNbz: N-acyl-N'-methyl-benzimidazolinone) and a cysteinyl peptide in the absence of thiol additives. The method enabled one-pot desulfurization and iodine oxidation after NCL....
8.
Tsuda S, Mochizuki M, Sakamoto K, Denda M, Nishio H, Otaka A, et al.
Org Lett
. 2016 Nov;
18(22):5940-5943.
PMID: 27805411
An N-sulfanylethylaminooxybutyramide (SEAoxy) has been developed as a novel thioester equivalent for native chemical ligation. SEAoxy peptide was straightforwardly synthesized by conventional Fmoc solid-phase peptide synthesis without a problem. Moreover,...
9.
Sakamoto K, Tsuda S, Mochizuki M, Nohara Y, Nishio H, Yoshiya T
Chemistry
. 2016 Oct;
22(50):17940-17944.
PMID: 27709754
Various bioactive proteins have been synthesized by native chemical ligation (NCL) and its combination with subsequent desulfurization (e.g., conversion from Cys to Ala). In NCL, excess 4-mercaptophenylacetic acid (MPAA) is...
10.
Tsuda S, Mochizuki M, Nishio H, Yoshiya T
Chembiochem
. 2016 Sep;
17(22):2133-2136.
PMID: 27616000
We report a novel strategy for native chemical ligation (NCL). Alanines not located at a ligation site are temporarily replaced with cysteines, and this enables efficient thiol-additive-free NCL, with subsequent...