Hesham Saeed
Overview
Explore the profile of Hesham Saeed including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
150
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Recent Articles
1.
Abounar S, El-Nikhely N, Turkowski K, Savai R, Saeed H
Int J Mol Sci
. 2024 Aug;
25(16).
PMID: 39201772
Cancer cells can escape death and surveillance by the host immune system in various ways. Programmed cell death ligand 1 (PD-L1) is a transmembrane protein that is expressed by most...
2.
Alshamy R, El-Nikhely N, Nematalla H, Elkewedi M, Mahran E, Saeed H
Curr Pharm Biotechnol
. 2024 Jul;
PMID: 38994625
Background: Microbial L-asparaginase (L-ASNase, EC 3.5.1.1) is a pivotal biopharmaceutical drug-protein that catalyzes the hydrolysis of the non-essential amino acid L-asparagine (L-Asn) into L-aspartic acid (L-Asp) and ammonia , resulting...
3.
Shalaby M, Hamouda D, Khedr S, Mostafa H, Saeed H, Ghareeb A
PLoS One
. 2023 Oct;
18(10):e0282557.
PMID: 37862350
The creation of innovative wound-healing nanomaterials based on natural compounds emerges as a top research goal. This research aimed to create a gel containing collagen nanoparticles and evaluate its therapeutic...
4.
Abdelwahab M, Saeed H, Elnikhely N, Nematalla H
Acta Biochim Pol
. 2023 Sep;
70(3):615-622.
PMID: 37677845
Effective therapeutic strategies are urgently required to enhance the prognosis of patients suffering from KRAS mutations. Owing to the undruggable nature of KRAS, targeting downstream signaling pathways, namely PI3K/AKT/mTOR, shows...
5.
Ghobrial D, El-Nikhely N, Sheta E, Ragab H, Rostom S, Saeed H, et al.
Antioxidants (Basel)
. 2023 Mar;
12(3).
PMID: 36978885
Liver Fibrosis can be life-threatening if left untreated as it may lead to serious, incurable complications. The common therapeutic approach is to reverse the fibrosis while the intervention is still...
6.
Noby N, Johnson R, Tyzack J, Embaby A, Saeed H, Hussein A, et al.
Int J Mol Sci
. 2022 May;
23(9).
PMID: 35563094
Cold active esterases have gained great interest in several industries. The recently determined structure of a family IV cold active esterase (EstN7) from strain N1 was used to expand its...
7.
Anwar M, Shalaby M, Saeed H, Mostafa H, Hamouda D, Nounou H
Sci Rep
. 2022 Mar;
12(1):4871.
PMID: 35319009
Nile Tilapia fish scale collagen has high biodegradability, excellent biocompatibility, and low antigenicity. We assessed both the encapsulation efficiency of theophylline into Nile Tilapia fish scale-based collagen nanoparticles and their...
8.
Noby N, Auhim H, Winter S, Worthy H, Embaby A, Saeed H, et al.
Open Biol
. 2021 Dec;
11(12):210182.
PMID: 34847772
Here we determined the structure of a cold active family IV esterase (EstN7) cloned strain N1. EstN7 is a dimer with a classical α/β hydrolase fold. It has an acidic...
9.
Saeed H, Elsawy E, Shalaby M, Abdel-Fattah M, Hemida A, Eldoksh A, et al.
Prep Biochem Biotechnol
. 2021 Oct;
52(6):668-680.
PMID: 34612174
Microbial L-asparaginases are aminohydrolases that hydrolyze L-asparagine to L-aspartate. They are used to treat acute lymphoblastic leukemia and Hodgkin's lymphomas and in food industries. Increasing demand for L-ASNases is therefore...
10.
Saeed H, Hemida A, Abdel-Fattah M, Eldoksh A, Shalaby M, Nematalla H, et al.
Protein Expr Purif
. 2021 Jan;
181:105820.
PMID: 33440252
In previous studies Pseudomonas aeruginosal-ASNase complete coding sequence gene, 984 bp (GenBank accession number KU161101.2) was isolated by PCR, cloned into pET28a(+) vector, expressed in E. coli DE3(BL21) pLysS, purified...