Heqiao Zhang
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Explore the profile of Heqiao Zhang including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
749
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0
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Recent Articles
1.
Wang Y, Zhao L, Zhang Y, Wang Y, Tang J, Liu S, et al.
Sci Adv
. 2024 Dec;
10(50):eadr7116.
PMID: 39661676
Nipah virus, a member of the family, is a highly pathogenic nonsegmented, negative-sense RNA virus (nsNSV) which causes severe neurological and respiratory illnesses in humans. There are no available drugs...
2.
Zhou J, Zhang H, Huo P, Shen H, Huang Q, Yang L, et al.
Sci Rep
. 2024 Nov;
14(1):27062.
PMID: 39511348
The gut microbiome primarily generates short-chain fatty acids (SCFAs) by fermenting dietary fibers. Though previous studies have linked SCFAs to blood pressure, there remains a lack of research on the...
3.
Zhang R, Zhou J, Huo P, Zhang H, Shen H, Huang Q, et al.
Biol Trace Elem Res
. 2024 Sep;
PMID: 39320571
Evidence about effects of metal(loid)s on hypertension among adults is insufficient. The aim of our study was to evaluate the individual and joint associations between seven selected metal(loid)s and hypertension,...
4.
Wang X, Wang Y, Liu S, Zhang Y, Xu K, Ji L, et al.
Proc Natl Acad Sci U S A
. 2023 Jul;
120(30):e2307598120.
PMID: 37459529
The Clr6S complex, a class I histone deacetylase complex, functions as a zinc-dependent enzyme to remove acetyl groups from lysine residues in histone tails. We report here the cryo-EM structure...
5.
Ji L, Zhao L, Xu K, Gao H, Zhou Y, Kornberg R, et al.
Proc Natl Acad Sci U S A
. 2022 Nov;
119(48):e2214313119.
PMID: 36417436
Nucleosome acetyltransferase of H4 (NuA4), one of two major histone acetyltransferase complexes in specifically acetylates histone H2A and H4, resulting in increased transcriptional activity. Here we present a 3.8-4.0 Å...
6.
Discovery and characterization of novel potent BCR-ABL degraders by conjugating allosteric inhibitor
Liu H, Mi Q, Ding X, Lin C, Liu L, Ren C, et al.
Eur J Med Chem
. 2022 Oct;
244:114810.
PMID: 36306539
The oncogenic fusion protein BCR-ABL is the driving force of leukemogenesis in chronic myeloid leukemia (CML). Despite the great advance in CML treatment through the application of tyrosine kinase inhibitors...
7.
Zhang H, Chen D, Mattoo R, Bushnell D, Wang Y, Yuan C, et al.
Mol Cell
. 2021 Feb;
81(8):1781-1788.e4.
PMID: 33571424
Mediator is a universal adaptor for transcription control. It serves as an interface between gene-specific activator or repressor proteins and the general RNA polymerase II (pol II) transcription machinery. Previous...
8.
Wang Y, Graham L, Han Z, Eves R, Gruneberg A, Campbell R, et al.
Biochem J
. 2020 May;
477(12):2179-2192.
PMID: 32459306
Ice-binding proteins (IBPs) are found in many biological kingdoms where they protect organisms from freezing damage as antifreeze agents or inhibitors of ice recrystallization. Here, the crystal structure of recombinant...
9.
Wang Y, Zhang F, Nie Y, Shang G, Zhang H
Biochem Biophys Res Commun
. 2019 Jun;
516(2):540-545.
PMID: 31235255
Histidine biosynthesis, which is absent in animals, was shown to be highly conserved among gram-negative bacteria, thus making it an attractive target for antibiotic design. There are many fusion forms...
10.
Wu Z, Liang S, Song W, Lin G, Wang W, Zhang H, et al.
Front Plant Sci
. 2017 Dec;
8:1999.
PMID: 29213277
Leucine-rich repeat receptor-like kinases (LRR-RLKs) are widespread in different plant species and play important roles in growth and development. Germination inhibition is vital for the completion of seed maturation and...