Henry Sanchez
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Explore the profile of Henry Sanchez including associated specialties, affiliations and a list of published articles.
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15
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848
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Recent Articles
1.
Bakir A, McGoran A, Silburn B, Russell J, Nel H, Lusher A, et al.
Sci Rep
. 2024 Jun;
14(1):12714.
PMID: 38830923
Infrastructure is often a limiting factor in microplastics research impacting the production of scientific outputs and monitoring data. International projects are therefore required to promote collaboration and development of national...
2.
Lawrence J, Aguilar-Calvo P, Ojeda-Juarez D, Khuu H, Soldau K, Pizzo D, et al.
J Neurosci
. 2023 Apr;
43(21):3970-3984.
PMID: 37019623
Endolysosomal defects in neurons are central to the pathogenesis of prion and other neurodegenerative disorders. In prion disease, prion oligomers traffic through the multivesicular body (MVB) and are routed for...
3.
Ojeda-Juarez D, Lawrence J, Soldau K, Pizzo D, Wheeler E, Aguilar-Calvo P, et al.
Neurobiol Dis
. 2022 Jul;
172:105834.
PMID: 35905927
Synapse dysfunction and loss are central features of neurodegenerative diseases, caused in part by the accumulation of protein oligomers. Amyloid-β, tau, prion, and α-synuclein oligomers bind to the cellular prion...
4.
Goodwill V, Dryden I, Choi J, De Lillo C, Soldau K, Llibre-Guerra J, et al.
Exp Eye Res
. 2022 Jul;
222:109172.
PMID: 35803332
Sporadic Creutzfeldt-Jakob disease (sCJD) is the most commonly diagnosed human prion disease caused by the abnormal misfolding of the 'cellular' prion protein (PrP) into the transmissible 'scrapie-type' prion form (PrP)....
5.
Novak R, Ingram M, Marquez S, Das D, Delahanty A, Herland A, et al.
Nat Biomed Eng
. 2020 Jan;
4(4):407-420.
PMID: 31988458
Organ chips can recapitulate organ-level (patho)physiology, yet pharmacokinetic and pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here, we describe an 'interrogator' that employs liquid-handling robotics, custom software and...
6.
Aguilar-Calvo P, Sevillano A, Bapat J, Soldau K, Sandoval D, Altmeppen H, et al.
Acta Neuropathol
. 2019 Nov;
139(3):527-546.
PMID: 31673874
Cofactors are essential for driving recombinant prion protein into pathogenic conformers. Polyanions promote prion aggregation in vitro, yet the cofactors that modulate prion assembly in vivo remain largely unknown. Here...
7.
Vandeleur D, Chen C, Huang E, Connolly A, Sanchez H, Moon-Grady A
Am J Med Genet A
. 2019 Oct;
179(12):2486-2489.
PMID: 31587467
Pathogenic DNM1L mutations cause a mitochondrial disorder with a highly variable clinical phenotype characterized by developmental delay, hypotonia, seizures, microcephaly, poor feeding, ocular abnormalities, and dysarthria. We report the case...
8.
Park T, Mustafaoglu N, Herland A, Hasselkus R, Mannix R, FitzGerald E, et al.
Nat Commun
. 2019 Jun;
10(1):2621.
PMID: 31197168
The high selectivity of the human blood-brain barrier (BBB) restricts delivery of many pharmaceuticals and therapeutic antibodies to the central nervous system. Here, we describe an in vitro microfluidic organ-on-a-chip...
9.
Orru C, Soldau K, Cordano C, Llibre-Guerra J, Green A, Sanchez H, et al.
mBio
. 2018 Nov;
9(6).
PMID: 30459197
Sporadic Creutzfeldt-Jakob disease (sCJD) is the most common prion disease in humans and has been iatrogenically transmitted through corneal graft transplantation. Approximately 40% of sCJD patients develop visual or oculomotor...
10.
Tousseyn T, Bajsarowicz K, Sanchez H, Gheyara A, Oehler A, Geschwind M, et al.
J Neuropathol Exp Neurol
. 2015 Jul;
74(9):873-88.
PMID: 26226132
We examined the brains of 266 patients with prion disease (PrionD) and found that 46 patients (17%) had Alzheimer disease (AD)-like changes. To explore potential mechanistic links between PrionD and...