Henry J McSorley
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Explore the profile of Henry J McSorley including associated specialties, affiliations and a list of published articles.
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2914
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Recent Articles
1.
Colomb F, McSorley H
Curr Opin Microbiol
. 2025 Feb;
84:102582.
PMID: 39954371
Parasitic nematodes release a wide variety of immunomodulatory proteins, which allow them to escape the host's immune-mediated killing or ejection mechanisms. This immunomodulation is mediated by nematode excretory/secretory (E/S) products,...
2.
Fleming C, McSorley H, Allen J, Petri W
bioRxiv
. 2024 Dec;
PMID: 39651252
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), remains a significant threat to global public health. Immunopathological damage plays a role in driving...
3.
Colomb F, Jamwal A, Ogunkanbi A, Frangova T, Savage A, Kelly S, et al.
Elife
. 2024 Nov;
13.
PMID: 39514278
The parasitic nematode secretes the HpARI family, which bind to IL-33, either suppressing (HpARI1 and HpARI2) or enhancing (HpARI3) responses to the cytokine. We previously showed that HpARI2 also bound...
4.
5.
Burgess M, Janas P, Berry K, Mayr H, Mack M, Jenkins S, et al.
Allergy
. 2024 Jun;
79(8):2157-2172.
PMID: 38924546
Background: Respiratory syncytial virus (RSV) infection in infants is a major cause of viral bronchiolitis and hospitalisation. We have previously shown in a murine model that ongoing infection with the...
6.
Jamwal A, Colomb F, McSorley H, Higgins M
Nat Commun
. 2024 Jun;
15(1):5226.
PMID: 38890291
IL-33 plays a significant role in inflammation, allergy, and host defence against parasitic helminths. The model gastrointestinal nematode Heligmosomoides polygyrus bakeri secretes the Alarmin Release Inhibitor HpARI2, an effector protein...
7.
Di Carmine S, Scott M, McLean M, McSorley H
Discov Immunol
. 2024 Apr;
1(1):kyac006.
PMID: 38566909
Interleukin (IL)-33 is highly expressed in the nucleus of cells present at barrier sites and signals via the ST2 receptor. IL-33 signalling via ST2 is essential for return to tissue...
8.
Lenz B, Ehrens A, Ajendra J, Risch F, Gal J, Neumann A, et al.
PLoS Pathog
. 2024 Mar;
20(3):e1012071.
PMID: 38457461
Background: Eosinophilia is a hallmark of helminth infections and eosinophils are essential in the protective immune responses against helminths. Nevertheless, the distinct role of eosinophils during parasitic filarial infection, allergy...
9.
Colomb F, Ogunkanbi A, Jamwal A, Dong B, Maizels R, Finney C, et al.
Infect Immun
. 2024 Jan;
92(3):e0039523.
PMID: 38294241
HpARI is an immunomodulatory protein secreted by the intestinal nematode , which binds and blocks IL-33. Here, we find that the genome contains three HpARI family members and that these...
10.
Reese A, de Moliner F, Mendive-Tapia L, Benson S, Kuru E, Bridge T, et al.
ACS Cent Sci
. 2024 Jan;
10(1):143-154.
PMID: 38292608
The essential functions that cytokine/immune cell interactions play in tissue homeostasis and during disease have prompted the molecular design of targeted fluorophores to monitor their activity in real time. Whereas...