Stephen M Anderton
Overview
Explore the profile of Stephen M Anderton including associated specialties, affiliations and a list of published articles.
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98
Citations
4943
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Recent Articles
1.
Licht-Mayer S, Campbell G, Mehta A, McGill K, Symonds A, Al-Azki S, et al.
Neuropathol Appl Neurobiol
. 2022 Oct;
49(1):e12851.
PMID: 36181265
Aims: Axonal injury in multiple sclerosis (MS) and experimental models is most frequently detected in acutely demyelinating lesions. We recently reported a compensatory neuronal response, where mitochondria move to the...
2.
Pohar J, OConnor R, Manfroi B, El-Behi M, Jouneau L, Boudinot P, et al.
Eur J Immunol
. 2022 May;
52(8):1335-1349.
PMID: 35579560
CD4 FOXP3 Tregs are currently explored to develop cell therapies against immune-mediated disorders, with an increasing focus on antigen receptor-engineered Tregs. Deciphering their mode of action is necessary to identify...
3.
Crittenden S, Goepp M, Pollock J, Robb C, Smyth D, Zhou Y, et al.
Sci Adv
. 2021 Feb;
7(7).
PMID: 33579710
The gut microbiota fundamentally regulates intestinal homeostasis and disease partially through mechanisms that involve modulation of regulatory T cells (T), yet how the microbiota-T cross-talk is physiologically controlled is incompletely...
4.
White M, Johnston C, Grainger J, Konkel J, OConnor R, Anderton S, et al.
Front Immunol
. 2020 Oct;
11:1830.
PMID: 33117327
Helminth parasites are effective in biasing Th2 immunity and inducing regulatory pathways that minimize excessive inflammation within their hosts, thus allowing chronic infection to occur whilst also suppressing bystander atopic...
5.
Licht-Mayer S, Campbell G, Canizares M, Mehta A, Gane A, McGill K, et al.
Acta Neuropathol
. 2020 Jun;
140(2):143-167.
PMID: 32572598
Axonal loss is the key pathological substrate of neurological disability in demyelinating disorders, including multiple sclerosis (MS). However, the consequences of demyelination on neuronal and axonal biology are poorly understood....
6.
Mair I, Besusso D, Saul L, Patel S, Ravindran R, McPherson R, et al.
Eur J Immunol
. 2018 Nov;
49(1):112-120.
PMID: 30485411
T cell adaptation is an important peripheral tolerogenic process which ensures that the T cell population can respond effectively to pathogens but remains tolerant to self-antigens. We probed the mechanisms...
7.
Crittenden S, Cheyne A, Adams A, Forster T, Robb C, Felton J, et al.
Immunol Cell Biol
. 2018 May;
96(10):1049-1059.
PMID: 29758102
Inflammatory bowel disease (IBD) is a condition of chronic inflammatory intestinal disorder with increasing prevalence but limited effective therapies. The purine metabolic pathway is involved in various inflammatory processes including...
8.
Lyall M, Cartier J, Richards J, Cobice D, Thomson J, Meehan R, et al.
Wellcome Open Res
. 2018 May;
2:67.
PMID: 29707653
: Non-alcoholic fatty liver disease (NAFLD) is a global health issue. Dietary methyl donor restriction is used to induce a NAFLD/non-alcoholic steatohepatitis (NASH) phenotype in rodents, however the extent to...
9.
Felton J, Duffin R, Robb C, Crittenden S, Anderton S, Howie S, et al.
Thorax
. 2018 Mar;
73(11):1081-1084.
PMID: 29574419
Acute lung injury is a neutrophil-dominant, life-threatening disease without effective therapies and better understanding of the pathophysiological mechanisms involved is an urgent need. Here we show that interleukin (IL)-22 is...
10.
A Context-Dependent Role for αv Integrins in Regulatory T Cell Accumulation at Sites of Inflammation
Mair I, Zandee S, Toor I, Saul L, McPherson R, Leech M, et al.
Front Immunol
. 2018 Mar;
9:264.
PMID: 29535709
Several inflammatory diseases including multiple sclerosis and inflammatory bowel disease have been associated with dysfunctional and/or reduced numbers of Foxp3 regulatory T cells (Treg). While numerous mechanisms of action have...