Henok Kassahun
Overview
Explore the profile of Henok Kassahun including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
1047
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0
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Recent Articles
1.
SenGupta T, Palikaras K, Esbensen Y, Konstantinidis G, Galindo F, Achanta K, et al.
Cell Rep
. 2021 Sep;
36(10):109668.
PMID: 34496255
Aging, genomic stress, and mitochondrial dysfunction are risk factors for neurodegenerative pathologies, such as Parkinson disease (PD). Although genomic instability is associated with aging and mitochondrial impairment, the underlying mechanisms...
2.
Fang E, Hou Y, Lautrup S, Borch Jensen M, Yang B, SenGupta T, et al.
Nat Commun
. 2019 Nov;
10(1):5284.
PMID: 31754102
Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase. WS patients exhibit...
3.
Zheleva A, Gomez-Orte E, Saenz-Narciso B, Ezcurra B, Kassahun H, de Toro M, et al.
PLoS Genet
. 2019 Sep;
15(9):e1008338.
PMID: 31525188
Animal development requires the execution of specific transcriptional programs in different sets of cells to build tissues and functional organs. Transcripts are exported from the nucleus to the cytoplasm where...
4.
Torgovnick A, Schiavi A, Shaik A, Kassahun H, Maglioni S, Rea S, et al.
EMBO Rep
. 2018 Oct;
19(12).
PMID: 30366941
Interventions that promote healthy aging are typically associated with increased stress resistance. Paradoxically, reducing the activity of core biological processes such as mitochondrial or insulin metabolism promotes the expression of...
5.
SenGupta T, Torgersen M, Kassahun H, Vellai T, Simonsen A, Nilsen H
Nat Commun
. 2018 Mar;
9:16206.
PMID: 29595188
This corrects the article DOI: 10.1038/ncomms3674.
6.
Fang E, Palikaras K, Sun N, Fivenson E, Spangler R, Kerr J, et al.
J Vis Exp
. 2017 Dec;
(129).
PMID: 29286376
Mitochondria are the powerhouses of cells and produce cellular energy in the form of ATP. Mitochondrial dysfunction contributes to biological aging and a wide variety of disorders including metabolic diseases,...
7.
Kassahun H, SenGupta T, Schiavi A, Maglioni S, Skjeldam H, Arczewska K, et al.
DNA Repair (Amst)
. 2017 Dec;
61:46-55.
PMID: 29202295
Oxidation of DNA bases, an inevitable consequence of oxidative stress, requires the base excision repair (BER) pathway for repair. Caenorhabditis elegans is a well-established model to study phenotypic consequences and...
8.
Fang E, Waltz T, Kassahun H, Lu Q, Kerr J, Morevati M, et al.
Sci Rep
. 2017 Apr;
7:46208.
PMID: 28397803
Aging is a major international concern that brings formidable socioeconomic and healthcare challenges. Small molecules capable of improving the health of older individuals are being explored. Small molecules that enhance...
9.
Scheibye-Knudsen M, Tseng A, Borch Jensen M, Scheibye-Alsing K, Fang E, Iyama T, et al.
Proc Natl Acad Sci U S A
. 2016 Nov;
113(44):12502-12507.
PMID: 27791127
Cockayne syndrome is a neurodegenerative accelerated aging disorder caused by mutations in the CSA or CSB genes. Although the pathogenesis of Cockayne syndrome has remained elusive, recent work implicates mitochondrial...
10.
Fang E, Kassahun H, Croteau D, Scheibye-Knudsen M, Marosi K, Lu H, et al.
Cell Metab
. 2016 Oct;
24(4):566-581.
PMID: 27732836
Ataxia telangiectasia (A-T) is a rare autosomal recessive disease characterized by progressive neurodegeneration and cerebellar ataxia. A-T is causally linked to defects in ATM, a master regulator of the response...