Helmuth Gehart
Overview
Explore the profile of Helmuth Gehart including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
2326
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Recent Articles
1.
Andersson-Rolf A, Groot K, Korving J, Begthel H, Hanegraaf M, VanInsberghe M, et al.
Cell
. 2024 Dec;
187(26):7394-7413.e22.
PMID: 39626658
The mammalian pancreas consists of three epithelial compartments: the acini and ducts of the exocrine pancreas and the endocrine islets of Langerhans. Murine studies indicate that these three compartments derive...
2.
Cullot G, Aird E, Schlapansky M, Yeh C, van de Venn L, Vykhlyantseva I, et al.
Nat Biotechnol
. 2024 Nov;
PMID: 39604565
The DNA-PKcs inhibitor AZD7648 enhances CRISPR-Cas9-directed homology-directed repair efficiencies, with potential for clinical utility, but its possible on-target consequences are unknown. We found that genome editing with AZD7648 causes frequent...
3.
Narayan N, Requena D, Lalazar G, Ramos-Espiritu L, Ng D, Levin S, et al.
Stem Cell Reports
. 2022 Jul;
17(8):1874-1888.
PMID: 35803261
Fibrolamellar carcinoma (FLC) is a rare, often lethal, liver cancer affecting adolescents and young adults, for which there are no approved therapeutics. The development of therapeutics is hampered by a...
4.
De Crignis E, Hossain T, Romal S, Carofiglio F, Moulos P, Khalid M, et al.
Elife
. 2021 Jul;
10.
PMID: 34328417
The molecular events that drive hepatitis B virus (HBV)-mediated transformation and tumorigenesis have remained largely unclear, due to the absence of a relevant primary model system. Here we propose the...
5.
Bonis V, Rossell C, Gehart H
Front Cell Dev Biol
. 2021 Jun;
9:661931.
PMID: 34095127
The single-layered, simple epithelium of the gastro-intestinal tract controls nutrient uptake, coordinates our metabolism and shields us from pathogens. Despite its seemingly simple architecture, the intestinal lining consists of highly...
6.
Marsee A, Roos F, Verstegen M, Gehart H, de Koning E, Lemaigre F, et al.
Cell Stem Cell
. 2021 May;
28(5):816-832.
PMID: 33961769
Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also...
7.
Bannier-Helaouet M, Post Y, Korving J, Trani Bustos M, Gehart H, Begthel H, et al.
Cell Stem Cell
. 2021 Mar;
28(7):1221-1232.e7.
PMID: 33730555
The lacrimal gland is essential for lubrication and protection of the eye. Disruption of lacrimal fluid production, composition, or release results in dry eye, causing discomfort and damage to the...
8.
Verstegen M, Roos F, Burka K, Gehart H, Jager M, de Wolf M, et al.
Sci Rep
. 2020 Dec;
10(1):21900.
PMID: 33318612
The development, homeostasis, and repair of intrahepatic and extrahepatic bile ducts are thought to involve distinct mechanisms including proliferation and maturation of cholangiocyte and progenitor cells. This study aimed to...
9.
Takayama K, Weaver L, Lummertz da Rocha E, Lo Sardo V, Gehart H, Vu L
Cell Stem Cell
. 2020 Dec;
27(6):853-855.
PMID: 33275897
COVID-19 has unfortunately halted lab work, conferences, and in-person networking, which is especially detrimental to researchers just starting their labs. Through social media and our reviewer networks, we met some...
10.
Saltsman J, Hammond W, Narayan N, Requena D, Gehart H, Lalazar G, et al.
Cancers (Basel)
. 2020 Sep;
12(9).
PMID: 32962010
Hepatoblastoma is the most common childhood liver cancer. Although survival has improved significantly over the past few decades, there remains a group of children with aggressive disease who do not...