Helmut Jacobsen
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Explore the profile of Helmut Jacobsen including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
847
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Recent Articles
1.
Honer M, Polara A, Kuwabara H, Jacobsen H, Pahler A, Hartung T, et al.
J Labelled Comp Radiopharm
. 2023 Apr;
66(9):222-236.
PMID: 37095603
The beta-site amyloid precursor protein cleaving enzyme (BACE1) is responsible for initiating the generation of beta-amyloid, the major constituent of amyloid plaques in Alzheimer's disease (AD). The purpose of this...
2.
Lathuiliere A, Laversenne V, Astolfo A, Kopetzki E, Jacobsen H, Stampanoni M, et al.
Brain
. 2016 Mar;
139(Pt 5):1587-604.
PMID: 26956423
Passive immunization against misfolded toxic proteins is a promising approach to treat neurodegenerative disorders. For effective immunotherapy against Alzheimer's disease, recent clinical data indicate that monoclonal antibodies directed against the...
3.
Urich E, Schmucki R, Ruderisch N, Kitas E, Certa U, Jacobsen H, et al.
Sci Rep
. 2015 Sep;
5:14104.
PMID: 26411801
The blood-brain barrier and the blood-cerebrospinal fluid barrier prevent access of biotherapeutics to their targets in the central nervous system and therefore prohibit the effective treatment of neurological disorders. In...
4.
Jacobsen H, Ozmen L, Caruso A, Narquizian R, Hilpert H, Jacobsen B, et al.
J Neurosci
. 2014 Aug;
34(35):11621-30.
PMID: 25164658
Therapeutic approaches for prevention or reduction of amyloidosis are currently a main objective in basic and clinical research on Alzheimer's disease. Among the agents explored in clinical trials are anti-Aβ...
5.
Lathuiliere A, Bohrmann B, Kopetzki E, Schweitzer C, Jacobsen H, Moniatte M, et al.
Biomaterials
. 2013 Dec;
35(2):792-802.
PMID: 24344356
The controlled delivery of antibodies by immunoisolated bioimplants containing genetically engineered cells is an attractive and safe approach for chronic treatments. To reach therapeutic antibody levels there is a need...
6.
Woltering T, Wostl W, Hilpert H, Rogers-Evans M, Pinard E, Mayweg A, et al.
Bioorg Med Chem Lett
. 2013 Jun;
23(14):4239-43.
PMID: 23735744
A series of amides bearing a variety of amidine head groups was investigated as BACE1 inhibitors with respect to inhibitory activity in a BACE1 enzyme as well as a cell-based...
7.
Hilpert H, Guba W, Woltering T, Wostl W, Pinard E, Mauser H, et al.
J Med Chem
. 2013 Apr;
56(10):3980-95.
PMID: 23590342
An extensive fluorine scan of 1,3-oxazines revealed the power of fluorine(s) to lower the pKa and thereby dramatically change the pharmacological profile of this class of BACE1 inhibitors. The CF3...
8.
de Vera Mudry M, Regenass-Lechner F, Ozmen L, Altmann B, Festag M, Singer T, et al.
Int J Alzheimers Dis
. 2013 Jan;
2012:289412.
PMID: 23316412
The γ-secretase complex is a promising target in Alzheimer's disease because of its role in the amyloidogenic processing of β-amyloid precursor protein. This enzyme also catalyzes the cleavage of Notch...
9.
Tai L, Jacobsen H, Ozmen L, Flohr A, Jakob-Roetne R, Caruso A, et al.
J Pharmacokinet Pharmacodyn
. 2012 Apr;
39(3):227-37.
PMID: 22481485
Inhibition of the enzyme(s) that produce the Amyloid beta (Aβ) peptide, namely BACE and γ-secretase, is considered an attractive target for Alzheimer's disease therapy. However, the optimal pharmacokinetic-pharmacodynamic modelling method...
10.
Lubbers T, Flohr A, Jolidon S, David-Pierson P, Jacobsen H, Ozmen L, et al.
Bioorg Med Chem Lett
. 2011 Sep;
21(21):6554-8.
PMID: 21924610
We herein report the discovery of a new γ-secretase modulator class with an aminothiazole core starting from a HTS hit (3). Synthesis and SAR of this series are discussed. These...