Helge G Roider
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Explore the profile of Helge G Roider including associated specialties, affiliations and a list of published articles.
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17
Citations
717
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Recent Articles
1.
Roider H, Hoff S, Tseng S, Berndt S, Trautwein M, Filarsky K, et al.
Clin Exp Med
. 2024 Jun;
24(1):122.
PMID: 38856863
Regulatory T cells (Tregs) are known to facilitate tumor progression by suppressing CD8+ T cells within the tumor microenvironment (TME), thereby also hampering the effectiveness of immune checkpoint inhibitors (ICIs)....
2.
Jahn C, Ibrahim M, Busch J, Lin Q, Manchanda H, Mohr H, et al.
Bioinformatics
. 2023 Jun;
39(6).
PMID: 37261846
Summary: Multimodal single-cell sequencing data provide detailed views into the molecular biology of cells. To allow for interactive analyses of such rich data and to readily derive insights from it,...
3.
Kang B, Camps J, Fan B, Jiang H, Ibrahim M, Hu X, et al.
Genome Biol
. 2022 Dec;
23(1):265.
PMID: 36550535
Background: The tumor microenvironment (TME) has been shown to strongly influence treatment outcome for cancer patients in various indications and to influence the overall survival. However, the cells forming the...
4.
Camps J, Noel F, Liechti R, Massenet-Regad L, Rigade S, Gotz L, et al.
Cancer Res
. 2022 Dec;
83(3):363-373.
PMID: 36459564
Significance: The IMMUcan scDB database is an accessible supportive tool to analyze and decipher tumor-associated single-cell RNA sequencing data, allowing researchers to maximally use this data to provide new insights...
5.
Beatson R, Parente-Pereira A, Halim L, Cozzetto D, Hull C, Whilding L, et al.
Cell Rep Med
. 2022 Jan;
2(12):100473.
PMID: 35028614
Despite its role in cancer surveillance, adoptive immunotherapy using γδ T cells has achieved limited efficacy. To enhance trafficking to bone marrow, circulating Vγ9Vδ2 T cells are expanded in serum-free...
6.
Huetter J, Gritzan U, Gutcher I, Doecke W, Luetke-Eversloh M, Golfier S, et al.
Cancer Immunol Res
. 2020 Apr;
8(7):895-911.
PMID: 32312711
The immunoglobulin-like domain containing receptor 2 (ILDR2), a type I transmembrane protein belonging to the B7 family of immunomodulatory receptors, has been described to induce an immunosuppressive effect on T-cell...
7.
Khan M, Khaznadar S, Routila J, Ventela S, Schmid E, Gebhart B, et al.
Head Neck
. 2020 Jan;
42(4):625-635.
PMID: 31919967
Background: MET has emerged as target in head and neck squamous cell carcinoma (HNSCC). However, clinical data on MET inhibition in HNSCC are limited. Methods: HNSCC biopsies and cell lines...
8.
Roider H, Pavlova N, Kirov I, Slavov S, Slavov T, Uzunov Z, et al.
BMC Bioinformatics
. 2014 Mar;
15:68.
PMID: 24618344
Background: Information about drug-target relations is at the heart of drug discovery. There are now dozens of databases providing drug-target interaction data with varying scope, and focus. Therefore, and due...
9.
do Rego T, Roider H, de Carvalho F, Costa I
Bioinformatics
. 2012 Jun;
28(18):2297-303.
PMID: 22730432
Motivation: Blood cell development is thought to be controlled by a circuit of transcription factors (TFs) and chromatin modifications that determine the cell fate through activating cell type-specific expression programs....
10.
Thomas-Chollier M, Hufton A, Heinig M, OKeeffe S, Masri N, Roider H, et al.
Nat Protoc
. 2011 Nov;
6(12):1860-9.
PMID: 22051799
The transcription factor affinity prediction (TRAP) method calculates the affinity of transcription factors for DNA sequences on the basis of a biophysical model. This method has proven to be useful...