Helene Gingras
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Explore the profile of Helene Gingras including associated specialties, affiliations and a list of published articles.
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24
Citations
484
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Recent Articles
1.
Peillard-Fiorente F, Pham N, Gingras H, Godin C, Feng J, Leprohon P, et al.
Nucleic Acids Res
. 2024 Dec;
53(1.
PMID: 39673518
DNA transformation is key for phenotypic diversity and adaptation of Streptococcus pneumoniae including in the emergence of multidrug resistance (MDR). Under laboratory conditions, DNA transformation is facilitated by the artificial...
2.
Morrish F, Gingras H, Noonan J, Huang L, Sweet I, Kuok I, et al.
Biochem Biophys Res Commun
. 2024 Aug;
737:150478.
PMID: 39128225
Genetic polymorphisms in nuclear respiratory factor-1 (Nrf1), a key transcriptional regulator of nuclear-encoded mitochondrial proteins, have been linked to diabetes. Homozygous deletion of Nrf1 is embryonic lethal in mice. Our...
3.
Pham N, Gingras H, Godin C, Feng J, Groppi A, Nikolski M, et al.
mBio
. 2024 Aug;
15(9):e0136024.
PMID: 39120145
Importance: In the age of next-generation sequencing (NGS), while data-driven methods such as genome-wide association study (GWAS) and machine learning (ML) excel at finding patterns, functional validation can be challenging...
4.
Morrish F, Gingras H, Noonan J, Huang L, Sweet I, Kuok I, et al.
bioRxiv
. 2023 Nov;
PMID: 38014068
Genetic polymorphisms in nuclear respiratory factor-1 ( ), a key transcriptional regulator of nuclear-encoded mitochondrial proteins, have been linked to diabetes. Homozygous deletion of is embryonic lethal in mice. Our...
5.
Flahaut M, Leprohon P, Pham N, Gingras H, Bourbeau J, Papadopoulou B, et al.
Sci Rep
. 2023 Oct;
13(1):16622.
PMID: 37789055
Inuit of Nunavik are coping with living conditions that can influence respiratory health. Our objective was to investigate associations between respiratory health in Inuit communities and their airway microbiome. Oropharyngeal...
6.
Gingras H, Peillard-Fiorente F, Godin C, Patron K, Leprohon P, Ouellette M
Antimicrob Agents Chemother
. 2023 Jul;
67(8):e0039523.
PMID: 37409958
Two strains of Streptococcus pneumoniae, one expressing the methyltransferase Erm(B) and the other negative for (B), were selected for solithromycin resistance either with direct drug selection or with chemical mutagenesis...
7.
Gingras H, Dridi B, Leprohon P, Ouellette M
Microb Genom
. 2022 Oct;
8(10).
PMID: 36239591
No abstract available.
8.
Morelle C, Mukherjee A, Zhang J, Fani F, Khandelwal A, Gingras H, et al.
ACS Infect Dis
. 2021 Jul;
7(8):2472-2482.
PMID: 34282886
Chemotherapy against the neglected tropical disease visceral leishmaniasis (VL) is suboptimal with only four licensed drugs. Amphotericin B (AmB), despite its toxicity, remained a second line drug for a long...
9.
Gingras H, Patron K, Leprohon P, Ouellette M
Microb Genom
. 2020 Oct;
6(11).
PMID: 33074087
We report on the combination of chemical mutagenesis, azithromycin selection and next-generation sequencing (Mut-Seq) for the identification of small nucleotide variants that decrease the susceptibility of to the macrolide antibiotic...
10.
Bhattacharya A, Leprohon P, Bigot S, Padmanabhan P, Mukherjee A, Roy G, et al.
Nat Commun
. 2019 Dec;
10(1):5627.
PMID: 31819054
Current genome-wide screens allow system-wide study of drug resistance but detecting small nucleotide variants (SNVs) is challenging. Here, we use chemical mutagenesis, drug selection and next generation sequencing to characterize...