Helena M Kok
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Explore the profile of Helena M Kok including associated specialties, affiliations and a list of published articles.
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7
Citations
157
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Recent Articles
1.
Li S, van Dijk C, Meeldijk J, Kok H, Blommestein I, Verbakel A, et al.
Front Oncol
. 2021 Jun;
11:681967.
PMID: 34178673
Angiogenesis is crucial for normal development and homeostasis, but also plays a role in many diseases including cardiovascular diseases, autoimmune diseases, and cancer. Granzymes are serine proteases stored in the...
2.
Increased intra-articular granzyme M may trigger local IFN-λ1/IL-29 response in rheumatoid arthritis
Shan L, van den Hoogen L, Meeldijk J, Kok H, Jongeneel L, Boes M, et al.
Clin Exp Rheumatol
. 2019 Jun;
38(2):220-226.
PMID: 31172927
Objectives: Granzymes are serine proteases involved in eliminating tumour cells and virally infected cells. In addition, extracellular granzyme levels are elevated in inflammatory conditions, including several types of infection and...
3.
Kok H, van den Hoogen L, van Roon J, Adriaansen E, Fritsch-Stork R, Nguyen T, et al.
Rheumatology (Oxford)
. 2017 Oct;
56(12):2129-2134.
PMID: 28968826
Objectives: Granzymes (Grs) are serine proteases that eliminate virally infected or tumour cells by inducing apoptosis. GrB has been shown to be associated to the pathophysiology of SLE, whereas the...
4.
Church R, Ali I, Tate M, Lavin D, Krishnakumar A, Kok H, et al.
Am J Physiol Renal Physiol
. 2017 Jan;
312(6):F1141-F1157.
PMID: 28100499
Gremlin1 (Grem1), an antagonist of bone morphogenetic proteins, plays a key role in embryogenesis. A highly specific temporospatial gradient of Grem1 and bone morphogenetic protein signaling is critical to normal...
5.
Wensink A, Kok H, Meeldijk J, Fermie J, Froelich C, Hack C, et al.
Cell Death Discov
. 2016 Dec;
2:16084.
PMID: 28028441
Granzymes are serine proteases that, upon release from cytotoxic cells, induce apoptosis in tumor cells and virally infected cells. In addition, a role of granzymes in inflammation is emerging. Recently,...
6.
Hilhorst M, Kok H, Broekhuizen R, van Paassen P, van Breda Vriesman P, Goldschmeding R, et al.
Nephrol Dial Transplant
. 2015 Apr;
30(8):1291-9.
PMID: 25916872
Background: Outcome in patients with anti-neutrophil cytoplasmic antibodies (ANCA)-associated glomerulonephritis (AGN) is difficult to predict. Scoring of renal biopsies has significant but limited predictive value. We investigated whether analysis of...
7.
Kok H, Falke L, Goldschmeding R, Nguyen T
Nat Rev Nephrol
. 2014 Oct;
10(12):700-11.
PMID: 25311535
Chronic kidney disease (CKD) is a major health and economic burden with a rising incidence. During progression of CKD, the sustained release of proinflammatory and profibrotic cytokines and growth factors...