Helen K Matthews
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Explore the profile of Helen K Matthews including associated specialties, affiliations and a list of published articles.
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16
Citations
1332
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Recent Articles
1.
Ganguli S, Wyatt T, Nyga A, Lawson R, Meyer T, Baum B, et al.
Curr Biol
. 2023 Jun;
33(13):2728-2741.e3.
PMID: 37343559
Oncogenic Ras has been shown to change the way cancer cells divide by increasing the forces generated during mitotic rounding. In this way, Ras enables cancer cells to divide across...
2.
Nyga A, Ganguli S, Matthews H, Baum B
Trends Cell Biol
. 2022 Sep;
33(1):60-69.
PMID: 36175301
Mutations in RAS are key oncogenic drivers and therapeutic targets. Oncogenic Ras proteins activate a network of downstream signalling pathways, including extracellular signal-regulated kinase (ERK) and phosphatidylinositol 3-kinase (PI3K), promoting...
3.
Nyga A, Munoz J, Dercksen S, Fornabaio G, Uroz M, Trepat X, et al.
Sci Adv
. 2021 Oct;
7(42):eabg6467.
PMID: 34644109
The loss of epithelial homeostasis and the disruption of normal tissue morphology are hallmarks of tumor development. Here, we ask how the uniform activation oncogene affects the morphology and tissue...
4.
Matthews H, Bertoli C, de Bruin R
Nat Rev Mol Cell Biol
. 2021 Sep;
23(1):74-88.
PMID: 34508254
Cancer is a group of diseases in which cells divide continuously and excessively. Cell division is tightly regulated by multiple evolutionarily conserved cell cycle control mechanisms, to ensure the production...
5.
Ganguli S, Matthews H
Curr Biol
. 2021 Aug;
31(15):R957-R959.
PMID: 34375600
The role of altered tissue mechanics in early cancer development is not well understood. A new study reveals how oncogene activation generates force within a tissue to impact cell division...
6.
Monster J, Donker L, Vliem M, Win Z, Matthews H, Cheah J, et al.
J Cell Biol
. 2021 Mar;
220(5).
PMID: 33688935
Epithelia are continuously self-renewed, but how epithelial integrity is maintained during the morphological changes that cells undergo in mitosis is not well understood. Here, we show that as epithelial cells...
7.
Taubenberger A, Baum B, Matthews H
Front Cell Dev Biol
. 2020 Aug;
8:687.
PMID: 32850812
When animal cells enter mitosis, they round up to become spherical. This shape change is accompanied by changes in mechanical properties. Multiple studies using different measurement methods have revealed that...
8.
Matthews H, Ganguli S, Plak K, Taubenberger A, Win Z, Williamson M, et al.
Dev Cell
. 2020 Feb;
52(5):563-573.e3.
PMID: 32032547
To divide in a tissue, both normal and cancer cells become spherical and mechanically stiffen as they enter mitosis. We investigated the effect of oncogene activation on this process in...
9.
Dix C, Matthews H, Uroz M, McLaren S, Wolf L, Heatley N, et al.
Dev Cell
. 2018 Apr;
45(1):132-145.e3.
PMID: 29634933
Animal cells undergo a dramatic series of shape changes as they divide, which depend on re-modeling of cell-substrate adhesions. Here, we show that while focal adhesion complexes are disassembled during...
10.
Mchedlishvili N, Matthews H, Corrigan A, Baum B
BMC Biol
. 2018 Jan;
16(1):14.
PMID: 29361957
Background: Entry into mitosis triggers profound changes in cell shape and cytoskeletal organisation. Here, by studying microtubule remodelling in human flat mitotic cells, we identify a two-step process of interphase...