Helen J Jefferies
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Explore the profile of Helen J Jefferies including associated specialties, affiliations and a list of published articles.
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14
Citations
857
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Recent Articles
1.
High magnesium dialysate does not improve intradialytic hemodynamics or abrogate myocardial stunning
Jefferies H, Lemoine S, McIntyre C
Hemodial Int
. 2020 Aug;
24(4):506-515.
PMID: 32844540
Background: Hemodialysis (HD) induces myocardial stunning and is associated with adverse cardiovascular outcomes. Intradialytic hypotension is a modifiable determinant of myocardial stunning. Magnesium (Mg) is reported to be valuable in...
2.
McIntyre C, John S, Jefferies H
NDT Plus
. 2017 Jun;
1(6):383-391.
PMID: 28657024
Cardiovascular mortality is grossly elevated in patients with chronic kidney disease (CKD), and is associated with a wide variety of structural and functional abnormalities. These issues have driven additional attempts...
3.
Jefferies H, Tertti R, Wittfooth S, Burton J, Metsarinne K, Pettersson K, et al.
Hemodial Int
. 2016 Nov;
21(4):519-523.
PMID: 27866393
Introduction: Repetitive dialysis-induced cardiac injury is associated with elevated troponin levels, inflammation, and longitudinal reduction in cardiac function. Pathogenic autoantibodies to cardiac troponins (cTnAAb) produce inflammatory cardiomyopathy in murine models....
4.
Jefferies H, Tertti R, Wittfooth S, Burton J, Metsarinne K, Pettersson K, et al.
Nephron
. 2015 Mar;
129(3):171-8.
PMID: 25766334
Background/aims: Pregnancy-associated plasma protein-A (PAPP-A) is a putative marker of atheroma instability and ischaemic myocardial stress prior to necrosis. Total PAPP-A (tPAPP-A) levels in acute coronary syndromes predict adverse outcomes....
5.
Jefferies H, Crowley L, Harrison L, Szeto C, Li P, Schiller B, et al.
Nephron Clin Pract
. 2014 Nov;
128(1-2):141-6.
PMID: 25401768
Background/aims: Endotoxaemia, a driver of systemic inflammation, appears to be driven by dialysis-induced circulatory stress in haemodialysis (HD) patients. More frequent HD regimens are associated with lower ultrafiltration requirements, improved...
6.
Huang S, Crowley L, Jefferies H, Eldehni M, Odudu A, McIntyre C
Can J Cardiol
. 2014 Sep;
30(11):1422-8.
PMID: 25228129
Background: Strain analysis derived from the analysis of speckle tracked imaging echocardiography can be used to examine ventricular contractile functions. In this study, we examined the relationship of hemodialysis (HD)-induced...
7.
Breidthardt T, Burton J, Odudu A, Eldehni M, Jefferies H, McIntyre C
Clin J Am Soc Nephrol
. 2012 Jul;
7(8):1285-92.
PMID: 22822013
Background And Objectives: Circulating troponin T levels are frequently elevated in patients undergoing long-term dialysis. The pathophysiology underlying these elevations is controversial. Design, Setting, Participants, & Measurements: In 70 prevalent...
8.
David S, John S, Jefferies H, Sigrist M, Kumpers P, Kielstein J, et al.
Nephrol Dial Transplant
. 2011 Oct;
27(5):1867-72.
PMID: 21976741
Background: The pathophysiology of aggravated atherosclerosis in chronic kidney disease (CKD) is still incompletely understood. However, there is an increasing focus on non-traditional risk factors, including endothelial dysfunction. Angiopoietin-2 (Ang-2)...
9.
Jefferies H, Virk B, Schiller B, Moran J, McIntyre C
Clin J Am Soc Nephrol
. 2011 May;
6(6):1326-32.
PMID: 21597028
Background And Objectives: Recurrent hemodialysis (HD)-induced ischemic cardiac injury (myocardial stunning) is common and associated with high ultrafiltration (UF) requirements, intradialytic hypotension, long-term loss of systolic function, increased likelihood of...
10.
Jefferies H, Burton J, McIntyre C
Blood Purif
. 2011 Feb;
32(1):63-8.
PMID: 21346338
Background/aims: Haemodialysis-induced myocardial stunning is associated with intradialytic hypotension, increased likelihood of cardiovascular events and death. Dialysis at 35°C reduces stunning, but adverse thermal symptoms limit technique adoption. This study...