Helen Flick-Smith
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Explore the profile of Helen Flick-Smith including associated specialties, affiliations and a list of published articles.
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13
Citations
212
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Recent Articles
1.
Disulfiram, an alcohol dependence therapy, can inhibit the in vitro growth of Francisella tularensis
Hamblin K, Flick-Smith H, Barnes K, Pereira-Leal J, Surkont J, Hampson R, et al.
Int J Antimicrob Agents
. 2019 Apr;
54(1):85-88.
PMID: 31029736
Disulfiram (DSF) can help treat alcohol dependency by inhibiting aldehyde dehydrogenase (ALDH). Genomic analysis revealed that Francisella tularensis, the causative agent of tularemia, has lost all but one ALDH-like domain...
2.
Carlsson E, Thwaite J, Jenner D, Spear A, Flick-Smith H, Atkins H, et al.
PLoS One
. 2016 Jul;
11(7):e0158575.
PMID: 27391310
Toll-like receptors (TLRs) recognise invading pathogens and mediate downstream immune signalling via Toll/IL-1 receptor (TIR) domains. TIR domain proteins (Tdps) have been identified in multiple pathogenic bacteria and have recently...
3.
Tree J, Flick-Smith H, Elmore M, Rowland C
J Immunol Res
. 2014 Oct;
2014:237043.
PMID: 25333059
Understanding the interactions between host and pathogen is important for the development and assessment of medical countermeasures to infectious agents, including potential biodefence pathogens such as Bacillus anthracis, Ebola virus,...
4.
Otvos Jr L, Flick-Smith H, Fox M, Ostorhazi E, Dawson R, Wade J
Protein Pept Lett
. 2013 Oct;
21(4):374-81.
PMID: 24164262
Proline-rich antibacterial peptides protect experimental animals from bacterial challenge even if they are unable to kill the microorganisms in vitro. Their major in vivo modes of action are inhibition of...
5.
Rowland C, Hartley M, Flick-Smith H, Laws T, Eyles J, Oyston P
Microbes Infect
. 2012 Feb;
14(7-8):584-9.
PMID: 22370220
In this paper we evaluate the role of human γδ T cells in control of Francisella tularensis infection. Using an in vitro model of infection, a reduction in bacterial numbers...
6.
Thomas R, Davies C, Nunez A, Hibbs S, Flick-Smith H, Eastaugh L, et al.
J Med Microbiol
. 2010 Aug;
59(Pt 12):1415-1427.
PMID: 20798216
Deposition of Bacillus anthracis endospores within either the lungs or nasal passages of A/J mice after aerosol exposure was influenced by different particle sized aerosols and resulted in different infection...
7.
Eyles J, Unal B, Hartley M, Newstead S, Flick-Smith H, Prior J, et al.
Proteomics
. 2007 May;
7(13):2172-83.
PMID: 17533643
Stimulation of protective immune responses against intracellular pathogens is difficult to achieve using non-replicating vaccines. BALB/c mice immunized by intramuscular injection with killed Francisella tularensis (live vaccine strain) adjuvanted with...
8.
Chalton D, Musson J, Flick-Smith H, Walker N, McGregor A, Lamb H, et al.
Infect Immun
. 2006 Sep;
74(12):6624-31.
PMID: 16982834
Caf1, a chaperone-usher protein from Yersinia pestis, is a major protective antigen in the development of subunit vaccines against plague. However, recombinant Caf1 forms polymers of indeterminate size. We report...
9.
Shim H, Musson J, Harper H, McNeill H, Walker N, Flick-Smith H, et al.
Immunology
. 2006 Aug;
119(3):385-92.
PMID: 16919002
We mapped mouse CD4 T-cell epitopes located in three structurally distinct regions of the V antigen of Yersinia pestis. T-cell hybridomas specific for epitopes from each region were generated to...
10.
Zhang G, Flick-Smith H, McCauley J
Virus Res
. 2003 Nov;
97(2):89-102.
PMID: 14602200
The sub-cellular location and mechanism of membrane association of NS3 and NS2-3 polypeptides of bovine viral diarrhoea virus (BVDV) have been examined. Both NS3 and NS2-3 proteins were detected in...