The Impact of "omic" and Imaging Technologies on Assessing the Host Immune Response to Biodefence Agents

Overview

Journal J Immunol Res

Publisher Wiley

Specialty Allergy & Immunology

Date 2014 Oct 22

PMID 25333059

Citations 1

Authors

Julia A Tree

Helen Flick-Smith

Michael J Elmore

Caroline A Rowland

Affiliations

Soon will be listed here.

Abstract

Understanding the interactions between host and pathogen is important for the development and assessment of medical countermeasures to infectious agents, including potential biodefence pathogens such as Bacillus anthracis, Ebola virus, and Francisella tularensis. This review focuses on technological advances which allow this interaction to be studied in much greater detail. Namely, the use of "omic" technologies (next generation sequencing, DNA, and protein microarrays) for dissecting the underlying host response to infection at the molecular level; optical imaging techniques (flow cytometry and fluorescence microscopy) for assessing cellular responses to infection; and biophotonic imaging for visualising the infectious disease process. All of these technologies hold great promise for important breakthroughs in the rational development of vaccines and therapeutics for biodefence agents.

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