Helen Eachus
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Explore the profile of Helen Eachus including associated specialties, affiliations and a list of published articles.
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10
Citations
83
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Recent Articles
1.
Choi M, Cook A, Mungikar K, Eachus H, Tochwin A, Linke M, et al.
iScience
. 2024 Jul;
27(7):110160.
PMID: 38989456
Early life stress (ELS) is a major risk factor for developing psychiatric disorders, with glucocorticoids (GCs) implicated in mediating its effects in shaping adult phenotypes. In this process, exposure to...
2.
Nagpal J, Eachus H, Lityagina O, Ryu S
Eur J Neurosci
. 2024 Apr;
59(11):3134-3146.
PMID: 38602078
Early life stress (ELS) exposure alters stress susceptibility in later life and affects vulnerability to stress-related disorders, but how ELS changes the long-lasting responsiveness of the stress system is not...
3.
Eachus H, Choi M, Tochwin A, Kaspareit J, Ho M, Ryu S
Commun Biol
. 2024 Apr;
7(1):416.
PMID: 38580727
Exposure to excess glucocorticoid (GC) during early development is implicated in adult dysfunctions. Reduced adult hippocampal neurogenesis is a well-known consequence of exposure to early life stress or elevated GC,...
4.
Eachus H, Ryu S
J Exp Biol
. 2024 Mar;
227(Suppl_1).
PMID: 38449327
Exposure to stress during early life may alter the developmental trajectory of an animal by a mechanism known as adaptive plasticity. For example, to enhance reproductive success in an adverse...
5.
Eachus H, Oberski L, Paveley J, Bacila I, Ashton J, Esposito U, et al.
Dis Model Mech
. 2023 Aug;
16(9).
PMID: 37525888
Glucocorticoid resistance is commonly observed in depression, and has been linked to reduced expression and/or function of the glucocorticoid receptor (NR3C1 in human, hereafter referred to as GR). Previous studies...
6.
Eachus H, Ryu S, Placzek M, Wood J
Curr Opin Endocr Metab Res
. 2023 Jan;
26:100383.
PMID: 36632608
Release of corticotropin-releasing hormone (CRH) from CRH neurons activates the hypothalamo-pituitary-adrenal (HPA) axis, one of the main physiological stress response systems. Complex feedback loops operate in the HPA axis and...
7.
Eachus H, Choi M, Ryu S
Front Cell Dev Biol
. 2021 Aug;
9:657591.
PMID: 34368117
The early life period represents a window of increased vulnerability to stress, during which exposure can lead to long-lasting effects on brain structure and function. This stress-induced developmental programming may...
8.
Eachus H, Zaucker A, Oakes J, Griffin A, Weger M, Guran T, et al.
Endocrinology
. 2017 Sep;
158(12):4165-4173.
PMID: 28938470
Congenital adrenal hyperplasia is a group of common inherited disorders leading to glucocorticoid deficiency. Most cases are caused by 21-hydroxylase deficiency (21OHD). The systemic consequences of imbalanced steroid hormone biosynthesis...
9.
Eachus H, Bright C, Cunliffe V, Placzek M, Wood J, Watt P
Hum Mol Genet
. 2017 Mar;
26(11):1992-2005.
PMID: 28334933
Psychiatric disorders arise due to an interplay of genetic and environmental factors, including stress. Studies in rodents have shown that mutants for Disrupted-In-Schizophrenia-1 (DISC1), a well-accepted genetic risk factor for...
10.
Muthu V, Eachus H, Ellis P, Brown S, Placzek M
Development
. 2016 Jun;
143(14):2651-63.
PMID: 27317806
In the developing brain, growth and differentiation are intimately linked. Here, we show that in the zebrafish embryo, the homeodomain transcription factor Rx3 coordinates these processes to build the tuberal/anterior...