Helen E Kent
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Explore the profile of Helen E Kent including associated specialties, affiliations and a list of published articles.
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13
Citations
644
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Recent Articles
1.
Lee W, Selva K, Audsley J, Kent H, Reynaldi A, Schlub T, et al.
JCI Insight
. 2025 Jan;
10(4).
PMID: 39786918
BACKGROUNDThe immunogenicity of current influenza vaccines needs improvement. Inactivated influenza and COVID-19 mRNA vaccines can be coadministered, but randomized controlled trial data are lacking on whether the 2 vaccines are...
2.
Kent S, Li S, Amarasena T, Reynaldi A, Lee W, Leeming M, et al.
ACS Nano
. 2024 Sep;
18(39):27077-27089.
PMID: 39298422
Lipid nanoparticle mRNA vaccines are an exciting but emerging technology used in humans. There is limited understanding of the factors that influence their biodistribution and immunogenicity. Antibodies to poly(ethylene glycol)...
3.
Lee W, Audsley J, Trieu M, Reynaldi A, Aurelia L, Mehta P, et al.
J Clin Invest
. 2024 Jul;
134(17).
PMID: 38990644
BACKGROUNDThere is uncertainty about the timing of booster vaccination against COVID-19 in highly vaccinated populations during the present endemic phase of COVID-19. Studies focused on primary vaccination have previously suggested...
4.
Selva K, Ramanathan P, Haycroft E, Reynaldi A, Cromer D, Tan C, et al.
JCI Insight
. 2023 Sep;
8(18).
PMID: 37737263
Understanding mucosal antibody responses from SARS-CoV-2 infection and/or vaccination is crucial to develop strategies for longer term immunity, especially against emerging viral variants. We profiled serial paired mucosal and plasma...
5.
Selva K, Ramanathan P, Haycroft E, Tan C, Wang L, Downie L, et al.
Immunol Cell Biol
. 2023 Sep;
101(10):975-983.
PMID: 37670482
Mucosal antibodies play a key role in protection against breakthrough COVID-19 infections and emerging viral variants. Intramuscular adenovirus-based vaccination (Vaxzevria) only weakly induces nasal IgG and IgA responses, unless vaccinees...
6.
Lee W, Tan H, Reynaldi A, Esterbauer R, Koutsakos M, Nguyen J, et al.
Sci Adv
. 2023 Jul;
9(29):eadg5301.
PMID: 37478181
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection of vaccinated individuals is increasingly common with the circulation of highly immune evasive and transmissible Omicron variants. Here, we report the...
7.
Koutsakos M, Reynaldi A, Lee W, Nguyen J, Amarasena T, Taiaroa G, et al.
Immunity
. 2023 Mar;
56(4):879-892.e4.
PMID: 36958334
Although the protective role of neutralizing antibodies against COVID-19 is well established, questions remain about the relative importance of cellular immunity. Using 6 pMHC multimers in a cohort with early...
8.
Kristensen A, Wragg K, Vanderven H, Lee W, Silvers J, Kent H, et al.
Clin Exp Immunol
. 2022 Sep;
210(2):163-174.
PMID: 36053502
Natural killer (NK) cells are important anti-viral effector cells. The function and phenotype of the NK cells that constitute an individual's NK cell repertoire can be influenced by ongoing or...
9.
Koutsakos M, Lee W, Reynaldi A, Tan H, Gare G, Kinsella P, et al.
Immunity
. 2022 Jun;
55(7):1316-1326.e4.
PMID: 35690062
Vaccination against SARS-CoV-2 protects from infection and improves clinical outcomes in breakthrough infections, likely reflecting residual vaccine-elicited immunity and recall of immunological memory. Here, we define the early kinetics of...
10.
Wragg K, Lee W, Koutsakos M, Tan H, Amarasena T, Reynaldi A, et al.
Nat Immunol
. 2022 Mar;
23(5):768-780.
PMID: 35314848
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination elicit CD4 T cell responses to the spike protein, including circulating follicular helper T (cT) cells that correlate with neutralizing...