Heinz Steffens
Overview
Explore the profile of Heinz Steffens including associated specialties, affiliations and a list of published articles.
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35
Citations
1076
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Recent Articles
1.
Moosmayer T, Kiszka K, Westphal V, Pape J, Leutenegger M, Steffens H, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
121(52):e2422020121.
PMID: 39705311
Optical imaging access to nanometer-level protein distributions in intact tissue is a highly sought-after goal, as it would provide visualization in physiologically relevant contexts. Under the unfavorable signal-to-background conditions of...
2.
Wegner W, Steffens H, Gregor C, Wolf F, Willig K
Elife
. 2022 Feb;
11.
PMID: 35195066
Synaptic plasticity underlies long-lasting structural and functional changes to brain circuitry and its experience-dependent remodeling can be fundamentally enhanced by environmental enrichment. It is however unknown, whether and how the...
3.
Steffens H, Mott A, Li S, Wegner W, Svehla P, Kan V, et al.
Sci Adv
. 2021 Jun;
7(24).
PMID: 34108204
Excitatory synapses on dendritic spines of pyramidal neurons are considered a central memory locus. To foster both continuous adaption and the storage of long-term information, spines need to be plastic...
4.
Willig K, Wegner W, Muller A, Calvet-Fournier V, Steffens H
Cell Rep
. 2021 Jun;
35(9):109192.
PMID: 34077731
Despite the tremendous success of super-resolution microscopy, multi-color in vivo applications are still rare. Here we present live-cell multi-label STED microscopy in vivo and in vitro by combining spectrally separated...
5.
Steffens H, Wegner W, Willig K
Methods
. 2019 May;
174:42-48.
PMID: 31132408
Superresolution microscopy techniques are now widely used, but their application in living animals remains a challenging task. The first superresolution imaging in a live vertebrate was demonstrated with STED microscopy...
6.
Masch J, Steffens H, Fischer J, Engelhardt J, Hubrich J, Keller-Findeisen J, et al.
Proc Natl Acad Sci U S A
. 2018 Aug;
115(34):E8047-E8056.
PMID: 30082388
Extending superresolution fluorescence microscopy to living animals has remained a challenging frontier ever since the first demonstration of STED (stimulated emission depletion) nanoscopy in the mouse visual cortex. The use...
7.
Wegner W, Mott A, Grant S, Steffens H, Willig K
Sci Rep
. 2018 Jan;
8(1):219.
PMID: 29317733
The post-synaptic density (PSD) is an electron dense region consisting of ~1000 proteins, found at the postsynaptic membrane of excitatory synapses, which varies in size depending upon synaptic strength. PSD95...
8.
Wegner W, Ilgen P, Gregor C, van Dort J, Mott A, Steffens H, et al.
Sci Rep
. 2017 Sep;
7(1):11781.
PMID: 28924236
The study of proteins in dendritic processes within the living brain is mainly hampered by the diffraction limit of light. STED microscopy is so far the only far-field light microscopy...
9.
Maisky V, Mankivska O, Maznychenko A, Vlasenko O, Dovgan O, Schomburg E, et al.
Acta Histochem
. 2016 Oct;
118(7):659-664.
PMID: 27692234
The NADPH-diaphorase activity and Fos-immunoreactivity within the ventral horn of the lumbar spinal cord were studied in cats with acute unilateral myositis following injection of carrageenan into the m.m. gastrocnemius-soleus....
10.
Saab A, Tzvetavona I, Trevisiol A, Baltan S, Dibaj P, Kusch K, et al.
Neuron
. 2016 Jun;
91(1):119-32.
PMID: 27292539
Oligodendrocytes make myelin and support axons metabolically with lactate. However, it is unknown how glucose utilization and glycolysis are adapted to the different axonal energy demands. Spiking axons release glutamate...