Heinrich Steinmetz
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Explore the profile of Heinrich Steinmetz including associated specialties, affiliations and a list of published articles.
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43
Citations
770
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Recent Articles
1.
Pogorevc D, Tang Y, Hoffmann M, Zipf G, Bernauer H, Popoff A, et al.
ACS Synth Biol
. 2019 Apr;
8(5):1121-1133.
PMID: 30995838
Argyrins represent a family of cyclic octapeptides exhibiting promising antimicrobial, antitumorigenic and immunosuppressant activities. They derive from a nonribosomal peptide synthetase pathway, which was identified and characterized in this study...
2.
Muthukumar Y, Munkemer J, Mathieu D, Richter C, Schwalbe H, Steinmetz H, et al.
PLoS One
. 2018 Aug;
13(7):e0201605.
PMID: 30063768
The identification of inhibitors of eukaryotic protein biosynthesis, which are targeting single translation factors, is highly demanded. Here we report on a small molecule inhibitor, gephyronic acid, isolated from the...
3.
Hoffmann T, Krug D, Bozkurt N, Duddela S, Jansen R, Garcia R, et al.
Nat Commun
. 2018 Feb;
9(1):803.
PMID: 29476047
Some bacterial clades are important sources of novel bioactive natural products. Estimating the magnitude of chemical diversity available from such a resource is complicated by issues including cultivability, isolation bias...
4.
Charousova I, Steinmetz H, Medo J, Javorekova S, Wink J
Folia Microbiol (Praha)
. 2017 Feb;
62(4):305-315.
PMID: 28161814
Myxobacteria, a group of antimicrobial producing bacteria, have been successfully cultured and characterized from ten soil samples collected from different parts of Slovakia. A total of 79 myxobacteria belonging to...
5.
Steinmetz H, Li J, Fu C, Zaburannyi N, Kunze B, Harmrolfs K, et al.
Angew Chem Int Ed Engl
. 2016 Jul;
55(34):10113-7.
PMID: 27404448
Myxobacteria are well-established sources for novel natural products exhibiting intriguing bioactivities. We here report on haprolid (1) isolated from Byssovorax cruenta Har1. The compound exhibits an unprecedented macrolactone comprising four...
6.
Tautz T, Hoffmann J, Hoffmann T, Steinmetz H, Washausen P, Kunze B, et al.
Org Lett
. 2016 May;
18(11):2560-3.
PMID: 27220069
The isolation, structure elucidation, and synthesis of antalid (1), a novel secondary metabolite from Polyangium sp., is described herein. The structure elucidation of 1 was performed with the aid of...
7.
Lee W, Schaefer K, Qiao Y, Srisuknimit V, Steinmetz H, Muller R, et al.
J Am Chem Soc
. 2015 Dec;
138(1):100-3.
PMID: 26683668
Lysobactin, also known as katanosin B, is a potent antibiotic with in vivo efficacy against Staphylococcus aureus and Streptococcus pneumoniae. It was previously shown to inhibit peptidoglycan (PG) biosynthesis, but...
8.
Baumann S, Herrmann J, Raju R, Steinmetz H, Mohr K, Huttel S, et al.
Angew Chem Int Ed Engl
. 2014 Dec;
53(52):14605-9.
PMID: 25510965
The development of new antibiotics faces a severe crisis inter alia owing to a lack of innovative chemical scaffolds with activities against Gram-negative and multiresistant pathogens. Herein, we report highly...
9.
Reker D, Perna A, Rodrigues T, Schneider P, Reutlinger M, Monch B, et al.
Nat Chem
. 2014 Nov;
6(12):1072-8.
PMID: 25411885
Natural products have long been a source of useful biological activity for the development of new drugs. Their macromolecular targets are, however, largely unknown, which hampers rational drug design and...
10.
Scherer O, Steinmetz H, Kaether C, Weinigel C, Barz D, Kleinert H, et al.
Biochem Pharmacol
. 2014 Aug;
91(4):490-500.
PMID: 25107704
The macrolide archazolid inhibits vacuolar-type H(+)-ATPase (V-ATPase), a proton-translocating enzyme involved in protein transport and pH regulation of cell organelles, and potently suppresses cancer cell growth at low nanomolar concentrations....