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Heike Doppler

Explore the profile of Heike Doppler including associated specialties, affiliations and a list of published articles. Areas
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Articles 35
Citations 1786
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Recent Articles
1.
Bastea L, Liu X, Fleming A, Pandey V, Doppler H, Edenfield B, et al.
Nat Commun . 2024 Dec; 15(1):10547. PMID: 39627248
The development of pancreatic cancer requires both, acquisition of an oncogenic mutation in KRAS as well as an inflammatory insult. However, the physiological causes for pancreatic inflammation are less defined....
2.
Durand N, Borges S, Hall T, Bastea L, Doppler H, Edenfield B, et al.
Oncotarget . 2018 Dec; 9(91):36358-36370. PMID: 30555634
Phosphatidylinositol-4-phosphate 5-kinase type-1C (PIP5K1C) is a lipid kinase that regulates focal adhesion dynamics and cell attachment through site-specific formation of phosphatidylinositol-4,5-bisphosphate (PI4,5P). By comparing normal breast tissue to carcinoma and...
3.
Durand N, Bastea L, Doppler H, Eiseler T, Storz P
Sci Rep . 2017 Aug; 7(1):9524. PMID: 28842658
Dependent on their cellular localization, Protein Kinase D (PKD) enzymes regulate different processes including Golgi transport, cell signaling and response to oxidative stress. The localization of PKD within cells is...
4.
Liou G, Bastea L, Fleming A, Doppler H, Edenfield B, Dawson D, et al.
Cell Rep . 2017 May; 19(7):1322-1333. PMID: 28514653
The contributions of the innate immune system to the development of pancreatic cancer are still ill defined. Inflammatory macrophages can initiate metaplasia of pancreatic acinar cells to a duct-like phenotype...
5.
Cobbaut M, Derua R, Doppler H, Lou H, Vandoninck S, Storz P, et al.
Sci Rep . 2017 Apr; 7(1):887. PMID: 28428613
Protein kinases are essential molecules in life and their crucial function requires tight regulation. Many kinases are regulated via phosphorylation within their activation loop. This loop is embedded in the...
6.
Doppler H, Storz P
Front Oncol . 2017 Apr; 7:41. PMID: 28361035
Due to alterations in their metabolic activity and decreased mitochondrial efficiency, cancer cells often show increased generation of reactive oxygen species (ROS), but at the same time, to avoid cytotoxic...
7.
Durand N, Bastea L, Long J, Doppler H, Ling K, Storz P
Sci Rep . 2016 Oct; 6:35963. PMID: 27775029
Focal adhesions (FAs) are highly dynamic structures that are assembled and disassembled on a continuous basis. The balance between the two processes mediates various aspects of cell behavior, ranging from...
8.
Doppler H, Panayiotou R, Reid E, Maimo W, Bastea L, Storz P
Sci Rep . 2016 Sep; 6:33758. PMID: 27649783
Increased expression of PRKD1 and its gene product protein kinase D1 (PKD1) are linked to oncogenic signaling in pancreatic ductal adenocarcinoma, but a direct functional relationship to oncogenic KRas has...
9.
Liou G, Doppler H, DelGiorno K, Zhang L, Leitges M, Crawford H, et al.
Cell Rep . 2016 Mar; 14(10):2325-36. PMID: 26947075
The development of pancreatic cancer requires the acquisition of oncogenic KRas mutations and upregulation of growth factor signaling, but the relationship between these is not well established. Here, we show...
10.
Doppler H, Storz P
Cell Metab . 2015 Oct; 22(4):536-7. PMID: 26445507
Although metabolic reprogramming is a hallmark of oncogenic transformation and growth of primary tumor cells, little is known about how metabolic alterations impact metastasis. In this issue of Cell Metabolism,...