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Heidrun Vethe

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Articles 24
Citations 392
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Recent Articles
1.
Hossain M, Unger L, Larsen U, Altankhuyag A, Legoy T, Paulo J, et al.
Exp Cell Res . 2025 Feb; 446(2):114452. PMID: 39988124
Characterizing the initial stages of oncogenic transformation allows the identification of tumor-promoting processes before the inherent clonal selection of the aggressive clones. Here, we used global proteomics, genetic cell tracing,...
2.
Bjornstad O, Carrasco M, Finne K, Ardawatia V, Winge I, Askeland C, et al.
EBioMedicine . 2024 Sep; 108:105325. PMID: 39232464
Background: Presence of nerves in tumours, by axonogenesis and neurogenesis, is gaining increased attention for its impact on cancer initiation and development, and the new field of cancer neuroscience is...
3.
Kjolle S, Finne K, Birkeland E, Ardawatia V, Winge I, Aziz S, et al.
Nat Commun . 2023 Jun; 14(1):3724. PMID: 37349288
Cancers are often associated with hypoxia and metabolic reprogramming, resulting in enhanced tumor progression. Here, we aim to study breast cancer hypoxia responses, focusing on secreted proteins from low-grade (luminal-like)...
4.
Bjornstad O, Carrasco M, Finne K, Winge I, Askeland C, Arnes J, et al.
bioRxiv . 2023 May; PMID: 37205344
Tumor neurogenesis, a process by which new nerves invade tumors, is a growing area of interest in cancer research. Nerve presence has been linked to aggressive features of various solid...
5.
Berle M, Hestetun K, Vethe H, Chera S, Paulo J, Dahl O, et al.
Cancer Genomics Proteomics . 2022 Feb; 19(2):130-144. PMID: 35181583
Background/aim: Better stratification of the risk of relapse will help select the right patients for adjuvant treatment and improve targeted therapies for patients with colon cancer. Materials And Methods: To...
6.
Gupta M, Vethe H, Softic S, Rao T, Wagh V, Shirakawa J, et al.
Stem Cell Reports . 2020 Oct; 15(5):1067-1079. PMID: 33125875
The role of leptin receptor (OB-R) signaling in linking pluripotency with growth and development and the consequences of dysfunctional leptin signaling on progression of metabolic disease is poorly understood. Using...
7.
Okuyama T, Shirakawa J, Tajima K, Ino Y, Vethe H, Togashi Y, et al.
Int J Mol Sci . 2020 Oct; 21(21). PMID: 33105604
Abnormal hepatic insulin signaling is a cause or consequence of hepatic steatosis. DPP-4 inhibitors might be protective against fatty liver. We previously reported that the systemic inhibition of insulin receptor...
8.
Ghila L, Bjorlykke Y, Legoy T, Vethe H, Furuyama K, Chera S, et al.
Biomedicines . 2020 Jul; 8(7). PMID: 32605028
Mutations in the hepatocyte nuclear factor 4α (HNF4α) gene affect prenatal and postnatal pancreas development, being characterized by insulin-producing β-cell dysfunction. Little is known about the cellular and molecular mechanisms...
9.
Legoy T, Mathisen A, Salim Z, Vethe H, Bjorlykke Y, Abadpour S, et al.
Front Cell Dev Biol . 2020 Mar; 8:109. PMID: 32161757
Generating insulin-producing β-cells from human induced pluripotent stem cells is a promising cell replacement therapy for improving or curing insulin-dependent diabetes. The transplantation of end-stages differentiating cells into living hosts...
10.
Legoy T, Vethe H, Abadpour S, Strand B, Scholz H, Paulo J, et al.
Sci Rep . 2020 Jan; 10(1):414. PMID: 31942009
Cell replacement therapies hold great therapeutic potential. Nevertheless, our knowledge of the mechanisms governing the developmental processes is limited, impeding the quality of differentiation protocols. Generating insulin-expressing cells in vitro...