Heather Ordonez
Overview
Explore the profile of Heather Ordonez including associated specialties, affiliations and a list of published articles.
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10
Citations
465
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Recent Articles
1.
Marks P, Garcia S, Martinez Barrio A, Belhocine K, Bernate J, Bharadwaj R, et al.
Genome Res
. 2019 Mar;
29(4):635-645.
PMID: 30894395
Large-scale population analyses coupled with advances in technology have demonstrated that the human genome is more diverse than originally thought. To date, this diversity has largely been uncovered using short-read...
2.
Ejaz A, Ordonez H, Jacewicz A, Ferrao R, Shuman S
Nucleic Acids Res
. 2017 Nov;
46(1):442-455.
PMID: 29165676
Mycobacterial Lhr is a DNA damage-inducible superfamily 2 helicase that uses adenosine triphosphate (ATP) hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes en...
3.
Yan K, Janda C, Chang J, Zheng G, Larkin K, Luca V, et al.
Nature
. 2017 May;
545(7653):238-242.
PMID: 28467820
The canonical Wnt/β-catenin signalling pathway governs diverse developmental, homeostatic and pathological processes. Palmitoylated Wnt ligands engage cell-surface frizzled (FZD) receptors and LRP5 and LRP6 co-receptors, enabling β-catenin nuclear translocation and...
4.
Uson M, Ordonez H, Shuman S
J Bacteriol
. 2015 Jul;
197(19):3057-65.
PMID: 26170411
Unlabelled: Mycobacteria have a large and distinctive ensemble of DNA helicases that function in DNA replication, repair, and recombination. Little is known about the roster of RNA helicases in mycobacteria...
5.
Ordonez H, Shuman S
Nucleic Acids Res
. 2014 Oct;
42(20):12722-34.
PMID: 25352547
Mycobacterium smegmatis DinB2 is the founder of a clade of Y-family DNA polymerase that is naturally adept at utilizing rNTPs or dNTPs as substrates. Here we investigate the fidelity and...
6.
Ordonez H, Uson M, Shuman S
Nucleic Acids Res
. 2014 Sep;
42(17):11056-70.
PMID: 25200080
This study unveils Mycobacterium smegmatis DinB2 as the founder of a clade of Y-family DNA polymerase that is naturally adept at incorporating ribonucleotides by virtue of a leucine in lieu...
7.
Das U, Chauleau M, Ordonez H, Shuman S
Proc Natl Acad Sci U S A
. 2014 Jul;
111(31):11317-22.
PMID: 25049385
Many biological scenarios generate "dirty" DNA 3'-PO4 ends that cannot be sealed by classic DNA ligases or extended by DNA polymerases. The noncanonical ligase RtcB can "cap" these ends via...
8.
Ordonez H, Shuman S
J Biol Chem
. 2013 Apr;
288(20):14125-14134.
PMID: 23549043
We are interested in the distinctive roster of helicases of Mycobacterium, a genus of the phylum Actinobacteria that includes the human pathogen Mycobacterium tuberculosis and its avirulent relative Mycobacterium smegmatis....
9.
Ordonez H, Unciuleac M, Shuman S
Nucleic Acids Res
. 2012 Jan;
40(10):4604-14.
PMID: 22287622
The Escherichia coli RecQ DNA helicase participates in a pathway of DNA repair that operates in parallel to the recombination pathway driven by the multisubunit helicase-nuclease machine RecBCD. The model...
10.
Natsoulis G, Bell J, Xu H, Buenrostro J, Ordonez H, Grimes S, et al.
PLoS One
. 2011 Jul;
6(6):e21088.
PMID: 21738606
We have developed an integrated strategy for targeted resequencing and analysis of gene subsets from the human exome for variants. Our capture technology is geared towards resequencing gene subsets substantially...