Heather E Machado
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Explore the profile of Heather E Machado including associated specialties, affiliations and a list of published articles.
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13
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456
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Recent Articles
1.
Machado H, Obro N, Williams N, Tan S, Boukerrou A, Davies M, et al.
Nat Commun
. 2023 Aug;
14(1):5092.
PMID: 37608017
Clonal tracking of cells using somatic mutations permits exploration of clonal dynamics in human disease. Here, we perform whole genome sequencing of 323 haematopoietic colonies from 10 individuals with the...
2.
Machado H, Mitchell E, Obro N, Kubler K, Davies M, Leongamornlert D, et al.
Nature
. 2022 Aug;
608(7924):724-732.
PMID: 35948631
The lymphocyte genome is prone to many threats, including programmed mutation during differentiation, antigen-driven proliferation and residency in diverse microenvironments. Here, after developing protocols for expansion of single-cell lymphocyte cultures,...
3.
Kapun M, Nunez J, Bogaerts-Marquez M, Murga-Moreno J, Paris M, Outten J, et al.
Mol Biol Evol
. 2021 Sep;
38(12):5782-5805.
PMID: 34469576
Drosophila melanogaster is a leading model in population genetics and genomics, and a growing number of whole-genome data sets from natural populations of this species have been published over the...
4.
Machado H, Bergland A, Taylor R, Tilk S, Behrman E, Dyer K, et al.
Elife
. 2021 Jun;
10.
PMID: 34155971
To advance our understanding of adaptation to temporally varying selection pressures, we identified signatures of seasonal adaptation occurring in parallel among populations. Specifically, we estimated allele frequencies genome-wide from flies...
5.
Abascal F, Harvey L, Mitchell E, Lawson A, Lensing S, Ellis P, et al.
Nature
. 2021 Apr;
593(7859):405-410.
PMID: 33911282
Somatic mutations drive the development of cancer and may contribute to ageing and other diseases. Despite their importance, the difficulty of detecting mutations that are only present in single cells...
6.
Tovy A, Reyes J, Gundry M, Brunetti L, Lee-Six H, Petljak M, et al.
Cell Stem Cell
. 2020 Jul;
27(2):326-335.e4.
PMID: 32673568
DNA methyltransferase 3A (DNMT3A) is the most commonly mutated gene in clonal hematopoiesis (CH). Somatic DNMT3A mutations arise in hematopoietic stem cells (HSCs) many years before malignancies develop, but difficulties...
7.
Machado H, Lawrie D, Petrov D
Genetics
. 2019 Dec;
214(2):511-528.
PMID: 31871131
Codon usage bias (CUB), where certain codons are used more frequently than expected by chance, is a ubiquitous phenomenon and occurs across the tree of life. The dominant paradigm is...
8.
Renn S, Machado H, Duftner N, Sessa A, Harris R, Hofmann H
Genome
. 2017 Sep;
61(4):287-297.
PMID: 28945978
The diversity of mating systems among animals is astounding. Importantly, similar mating systems have evolved even across distantly related taxa. However, our understanding of the mechanisms underlying these convergently evolved...
9.
Machado H, Bergland A, OBrien K, Behrman E, Schmidt P, Petrov D
Mol Ecol
. 2015 Nov;
25(3):723-40.
PMID: 26523848
Examples of clinal variation in phenotypes and genotypes across latitudinal transects have served as important models for understanding how spatially varying selection and demographic forces shape variation within species. Here,...
10.
Machado H, Jui G, Joyce D, Reilly 3rd C, Lunt D, Renn S
BMC Genomics
. 2014 Feb;
15:161.
PMID: 24571567
Background: Gene duplication is a source of evolutionary innovation and can contribute to the divergence of lineages; however, the relative importance of this process remains to be determined. The explosive...