Hazhar Karim
Overview
Explore the profile of Hazhar Karim including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
23
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Recent Articles
1.
Fotoohi A, Karim H, Lafolie P, Pohanka A, Ostervall J, Hatschek T, et al.
Ther Drug Monit
. 2015 Oct;
38(2):239-45.
PMID: 26485084
Background: Tamoxifen is still an important antihormonal treatment option for patients with breast cancer and estrogen receptor-positive tumors. More than 20% of patients relapse despite treatment. The drug is usually...
2.
Karim H, Appell M, Fotoohi A
J Chromatogr B Analyt Technol Biomed Life Sci
. 2013 Oct;
939:80-5.
PMID: 24113235
Thiopurine efficacy is partly reflected by the genetic polymorphism of the thiopurine methyltransferase (TPMT) enzyme, which is responsible for variation in the metabolism, toxicity and therapeutic efficacy of the thiopurines...
3.
Karim H, Ghalali A, Lafolie P, Vitols S, Fotoohi A
Biochem Biophys Res Commun
. 2013 Jul;
437(2):280-6.
PMID: 23811272
The thiopurine antimetabolites, 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) are inactive pro-drugs that require intracellular metabolism for activation to cytotoxic metabolites. Thiopurine methyltransferase (TPMT) is one of the most important enzymes...
4.
Karim H, Bogason A, Bhuiyan H, Fotoohi A, Lafolie P, Vitols S
Curr Drug Deliv
. 2012 Oct;
10(4):404-12.
PMID: 23062181
Aims: The mechanisms behind cellular anthracycline uptake are not completely understood. Knowledge about uptake mechanisms could be used to increase the selectivity of the drugs. We compared the uptake patterns...
5.
Karim H, Hashemi J, Larsson C, Moshfegh A, Fotoohi A, Albertioni F
Biochem Biophys Res Commun
. 2011 Jul;
411(1):156-61.
PMID: 21723252
Exposure of MOLT4 human T-cell leukemia cells to 6-Mercaptopurine (6-MP) and 6-Thioguanine (6-TG) resulted in acquired resistance associated with attenuated expression of the genes encoding concentrative nucleoside transporter 3 (CNT3)...