Hazel F OConnor
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Explore the profile of Hazel F OConnor including associated specialties, affiliations and a list of published articles.
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9
Citations
215
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Recent Articles
1.
Heeke A, Elliott A, Feldman R, OConnor H, Pohlmann P, Lynce F, et al.
Breast Cancer Res Treat
. 2022 Sep;
196(2):279-289.
PMID: 36125660
Purpose: Estrogen receptor 1 (ESR1) mutations and fusions typically arise in patients with hormone receptor-positive breast cancer after aromatase inhibitor therapy, whereby ESR1 is constitutively activated in a ligand-independent manner....
2.
Burgess E, Livasy C, Trufan S, Zhu J, OConnor H, Hartman A, et al.
Mol Clin Oncol
. 2022 Apr;
16(5):102.
PMID: 35463214
Biomarkers are needed in muscle-invasive bladder cancer (MIBC). We previously reported that high tumor aurora kinase (AURK) A expression identifies patients with MIBC with poor prognosis. Aberrant p53 expression has...
3.
Osunkwo I, OConnor H, Saah E
Hematology Am Soc Hematol Educ Program
. 2020 Dec;
2020(1):562-569.
PMID: 33275672
Chronic pain in sickle cell disease (SCD) refers to pain present on most days lasting over six months. It can start during childhood and the prevalence increases with age. By...
4.
OConnor H, Swaim C, Canadeo L, Huibregtse J
Methods Mol Biol
. 2018 Sep;
1844:85-100.
PMID: 30242705
UBAITs (Ubiquitin-Activated Interaction Traps) are reagents that capitalize on the biochemistry of the ubiquitin system to covalently trap transient protein-protein interactions. UBAITs consist of an affinity-tagged protein of interest fused...
5.
OConnor H, Huibregtse J
Cell Mol Life Sci
. 2017 Apr;
74(18):3363-3375.
PMID: 28455558
Protein ubiquitylation is an important post-translational modification, regulating aspects of virtually every biochemical pathway in eukaryotic cells. Hundreds of enzymes participate in the conjugation and deconjugation of ubiquitin, as well...
6.
OConnor H, Lyon N, Leung J, Agarwal P, Swaim C, Miller K, et al.
EMBO Rep
. 2015 Oct;
16(12):1699-712.
PMID: 26508657
We describe a new class of reagents for identifying substrates, adaptors, and regulators of HECT and RING E3s. UBAITs (Ubiquitin-Activated Interaction Traps) are E3-ubiquitin fusion proteins and, in an E1-...
7.
Mooij M, OConnor H, Tian Z, Wang Y, Adams C, Morrissey J, et al.
Environ Microbiol Rep
. 2013 Jun;
2(3):461-4.
PMID: 23766121
Spontaneous nfxC-type phenotypic mutants of Pseudomonas aeruginosa are characterized by chloramphenicol resistance and increased expression of the multidrug efflux pump, MexEF-OprN. These mutants frequently arise during the propagation of bacteria...
8.
Hong S, Wang X, OConnor H, Benedik M, Wood T
Microb Biotechnol
. 2012 Jan;
5(4):509-22.
PMID: 22221537
Since persister cells cause chronic infections and since Escherichia coli toxin MqsR increases persisters, we used protein engineering to increase the toxicity of MqsR to gain insights into persister cell...
9.
Tian Z, Mac Aogain M, OConnor H, Fargier E, Mooij M, Adams C, et al.
Microb Pathog
. 2009 Aug;
47(4):237-41.
PMID: 19683048
In the human pathogen Pseudomonas aeruginosa, the LysR-family regulator MexT modulates the induction of the tripartite MexEF-OprN resistance nodulation-division multi-drug efflux system resulting in increased resistance to diverse antibiotics. The...