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Hassibullah Akeefe

Explore the profile of Hassibullah Akeefe including associated specialties, affiliations and a list of published articles. Areas
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Articles 6
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Recent Articles
1.
Liu S, Razon L, Ritchie O, Sihn C, Handyside B, Berguig G, et al.
Mol Ther Methods Clin Dev . 2022 Jul; 26:61-71. PMID: 35782594
Recombinant adeno-associated virus (AAV) is an effective platform for therapeutic gene transfer; however, tissue-tropism differences between species are a challenge for successful translation of preclinical results to humans. We evaluated...
2.
Sandza K, Clark A, Koziol E, Akeefe H, Yang F, Holcomb J, et al.
Gene Ther . 2021 Aug; 29(1-2):94-105. PMID: 34421119
Adeno-associated virus (AAV)-based gene therapy vectors are replication-incompetent and thus pose minimal risk for horizontal transmission or release into the environment. In studies with AAV5-FVIII-SQ (valoctocogene roxaparvovec), an investigational gene...
3.
Barajas D, Aponte-Ubillus J, Akeefe H, Cinek T, Peltier J, Gold D
PLoS One . 2017 Mar; 12(3):e0173010. PMID: 28355224
The yeast Saccharomyces cerevisiae has been successfully employed to establish model systems for a number of viruses. Such model systems are powerful tools to study the virus biology and in...
4.
Sacks F, Rudel L, Conner A, Akeefe H, Kostner G, Baki T, et al.
J Lipid Res . 2009 Jan; 50(5):894-907. PMID: 19144994
Uptake of cholesterol from peripheral cells by nascent small HDL circulating in plasma is necessary to prevent atherosclerosis. This process, termed reverse cholesterol transport, produces larger cholesterol-rich HDL that transfers...
5.
Kitabwalla M, Ansari A, Villinger F, Akeefe H, Conner A, Mayne A, et al.
Exp Biol Med (Maywood) . 2008 Apr; 233(6):732-40. PMID: 18408147
This pilot experiment in a simian immunodeficiency virus (SIV) chronic infection model aimed at extending our previous findings that vaccination with delipidated SIV resulted in more potent and diversified antiviral...
6.
Kitabwalla M, Villinger F, Akeefe H, Liao Z, Mayne A, Gargano L, et al.
Vaccine . 2005 Jun; 23(38):4666-77. PMID: 15955600
We tested the hypothesis that removal of viral lipids using diisopropylether can enhance antigenicity of SIVmac251. DIPE delipidation removed cholesterol from SIVmac251 without significant loss of viral protein or RNA....