Hassan Melhem
Overview
Explore the profile of Hassan Melhem including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
26
Citations
567
Followers
0
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Related Specialties
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Top 10 Co-Authors
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Recent Articles
21.
de Valliere C, Cosin-Roger J, Simmen S, Atrott K, Melhem H, Zeitz J, et al.
Cell Mol Gastroenterol Hepatol
. 2017 Feb;
2(6):796-810.
PMID: 28174749
Background & Aims: A novel family of proton-sensing G-protein-coupled receptors, including ovarian cancer G-protein-coupled receptor 1 (OGR1) (GPR68) has been identified to play a role in pH homeostasis. Hypoxia is...
22.
Gerstgrasser A, Melhem H, Leonardi I, Atrott K, Schafer M, Werner S, et al.
J Crohns Colitis
. 2016 Sep;
11(4):485-499.
PMID: 27683801
Background And Aims: The transcription factor Nrf2 is a major modulator of the cellular antioxidant response. Oxidative burst of infiltrating macrophages leads to a massive production of reactive oxygen species...
23.
Goffin L, Fagagnini S, Vicari A, Mamie C, Melhem H, Weder B, et al.
Inflamm Bowel Dis
. 2016 Aug;
22(9):2041-57.
PMID: 27542125
Background: Despite medical treatments or surgical options, more than one-third of patients with Crohn's disease suffer from recurring fistulae. Matrix metalloprotease 9 (MMP-9), a type IV collagenase that cleaves components...
24.
Feigerlova E, Demarquet L, Melhem H, Ghemrawi R, Battaglia-Hsu S, Ewu E, et al.
FASEB J
. 2016 Jul;
30(10):3598-3612.
PMID: 27435264
Deficiency in methyl donor (folate and vitamin B) and in vitamin D is independently associated with altered bone development. Previously, methyl donor deficiency (MDD) was shown to weaken the activity...
25.
Reinhard A, Sandborn W, Melhem H, Bolotine L, Chamaillard M, Peyrin-Biroulet L
Expert Rev Clin Immunol
. 2015 Apr;
11(5):637-57.
PMID: 25837708
Photodynamic therapy (PDT) is currently used as a minimally invasive therapeutic modality for cancer. Whereas antitumor treatment regimens require lethal doses of photosensitizer and light, sublethal doses may have immunomodulatory...
26.
Melhem H, Hansmannel F, Bressenot A, Battaglia-Hsu S, Billioud V, Alberto J, et al.
Gut
. 2015 Jan;
65(4):595-606.
PMID: 25608526
Background: Methyl donor deficiency (MDD) aggravates experimental colitis in rats and increases endoplasmic reticulum (ER) stress through decreased sirtuin 1 (SIRT1) in neuronal cells and myocardium. ER stress plays a...