Hassan Melhem
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Explore the profile of Hassan Melhem including associated specialties, affiliations and a list of published articles.
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26
Citations
567
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Recent Articles
11.
Maeyashiki C, Melhem H, Hering L, Baebler K, Cosin-Roger J, Schefer F, et al.
Sci Rep
. 2020 Jan;
10(1):1438.
PMID: 31996710
Proton-sensing ovarian cancer G-protein coupled receptor (OGR1) plays an important role in pH homeostasis. Acidosis occurs at sites of intestinal inflammation and can induce endoplasmic reticulum (ER) stress and the...
12.
Melhem H, Kaya B, Ayata C, Hruz P, Hendrik Niess J
Cells
. 2019 May;
8(5).
PMID: 31091682
Increasing evidence has indicated that diet and metabolites, including bacteria- and host-derived metabolites, orchestrate host pathophysiology by regulating metabolism, immune system and inflammation. Indeed, autoimmune diseases such as inflammatory bowel...
13.
Melhem H, Kallol S, Huang X, Luthi M, Ontsouka C, Keogh A, et al.
Sci Rep
. 2019 Apr;
9(1):6225.
PMID: 30996342
High levels of atherogenic lipids in pregnancy are associated with health complications for the mother, the fetus and the newborn. As endocrine secretory tissue, the human placenta releases apolipoproteins (apos),...
14.
Simmen S, Cosin-Roger J, Melhem H, Maliachovas N, Maane M, Baebler K, et al.
Cell Mol Gastroenterol Hepatol
. 2019 Feb;
7(2):339-355.
PMID: 30704983
Background & Aims: Hypoxia-associated pathways influence the development of inflammatory bowel disease. Adaptive responses to hypoxia are mediated through hypoxia-inducible factors, which are regulated by iron-dependent hydroxylases. Signals reflecting oxygen...
15.
Spalinger M, Atrott K, Baebler K, Schwarzfischer M, Melhem H, Peres D, et al.
J Crohns Colitis
. 2018 Dec;
13(6):785-797.
PMID: 30590526
Background And Aims: Inflammatory bowel disease [IBD] is accompanied by lesions in the epithelial barrier, which allow translocation of bacterial products from the gut lumen to the host's circulation. IMM-124E...
16.
Cosin-Roger J, Spalinger M, Ruiz P, Stanzel C, Terhalle A, Wolfram L, et al.
PLoS One
. 2018 Feb;
13(2):e0193003.
PMID: 29447283
Gp96 is an endoplasmic reticulum chaperone for multiple protein substrates. Its lack in intestinal macrophages of Crohn's disease (CD) patients is correlated with loss of tolerance against the host gut...
17.
Wang Y, de Valliere C, Silva P, Leonardi I, Gruber S, Gerstgrasser A, et al.
J Crohns Colitis
. 2017 Nov;
12(3):355-368.
PMID: 29136128
Background And Aims: During active inflammation, intraluminal intestinal pH is decreased in patients with inflammatory bowel disease [IBD]. Acidic pH may play a role in IBD pathophysiology. Recently, proton-sensing G-protein...
18.
Lopez A, Hansmannel F, Kokten T, Bronowicki J, Melhem H, Sokol H, et al.
Carcinogenesis
. 2017 Oct;
38(12):1157-1166.
PMID: 28968883
Evolution led to an essential symbiotic relationship between the host and commensal microbiota, regulating physiological functions including inflammation and immunity. This equilibrium can be disturbed by environmental factors such as...
19.
Cosin-Roger J, Simmen S, Melhem H, Atrott K, Frey-Wagner I, Hausmann M, et al.
Nat Commun
. 2017 Jul;
8(1):98.
PMID: 28740109
Hypoxia regulates autophagy and nucleotide-binding oligomerization domain receptor, pyrin domain containing (NLRP)3, two innate immune mechanisms linked by mutual regulation and associated to IBD. Here we show that hypoxia ameliorates...
20.
Melhem H, Spalinger M, Cosin-Roger J, Atrott K, Lang S, Wojtal K, et al.
J Crohns Colitis
. 2017 Feb;
11(7):871-884.
PMID: 28199527
Background And Aims: An imbalance between cellular antioxidant defence system[s] and reactive oxygen species [ROS]-driven oxidative stress has been implicated in the pathogenesis of inflammatory bowel disease. Peroxiredoxin [PRDX] 6...