Hassan Melhem
Overview
Explore the profile of Hassan Melhem including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
567
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Recent Articles
1.
Melhem H, Hendrik Niess J
Int J Mol Sci
. 2024 Aug;
25(15).
PMID: 39126102
Eosinophilic esophagitis (EoE) and inflammatory bowel disease (IBD) are chronic inflammatory disorders of the gastrointestinal tract, with EoE predominantly provoked by food and aeroallergens, whereas IBD is driven by a...
2.
Miyamoto K, Sujino T, Harada Y, Ashida H, Yoshimatsu Y, Yonemoto Y, et al.
Cell Rep
. 2023 Aug;
42(8):113005.
PMID: 37590143
The intricate interplay between gut microbes and the onset of experimental autoimmune encephalomyelitis (EAE) remains poorly understood. Here, we uncover remarkable similarities between CD4 T cells in the spinal cord...
3.
Kaymak T, Kaya B, Wuggenig P, Nuciforo S, Goldi A, Oswald F, et al.
Gut
. 2022 May;
72(5):821-833.
PMID: 35613844
Objective: Disruption of the epithelial barrier plays an essential role in developing eosinophilic oesophagitis (EoE), a disease defined by type 2 helper T cell (Th2)-mediated food-associated and aeroallergen-associated chronic inflammation....
4.
Melhem H, Kaya B, Kaymak T, Wuggenig P, Flint E, Roux J, et al.
Mucosal Immunol
. 2022 Mar;
15(3):443-458.
PMID: 35264769
Goblet cells secrete mucin to create a protective mucus layer against invasive bacterial infection and are therefore essential for maintaining intestinal health. However, the molecular pathways that regulate goblet cell...
5.
Lett M, Mehta H, Keogh A, Jaeger T, Jacquet M, Powell K, et al.
Gut
. 2022 Jan;
71(12):2526-2538.
PMID: 35058274
Objective: Mucosal-associated invariant T (MAIT) cells are the most abundant T cells in human liver. They respond to bacterial metabolites presented by major histocompatibility complex-like molecule MR1. MAIT cells exert...
6.
Melhem H, Regan-Komito D, Hendrik Niess J
Int J Mol Sci
. 2021 Dec;
22(24).
PMID: 34948435
Maintaining intestinal health requires clear segregation between epithelial cells and luminal microbes. The intestinal mucus layer, produced by goblet cells (GCs), is a key element in maintaining the functional protection...
7.
Kaya B, Melhem H, Hendrik Niess J
Front Immunol
. 2021 Nov;
12:717392.
PMID: 34790192
Diet and gut microbial metabolites mediate host immune responses and are central to the maintenance of intestinal health. The metabolite-sensing G-protein coupled receptors (GPCRs) bind metabolites and trigger signals that...
8.
Kaya B, Donas C, Wuggenig P, Diaz O, Morales R, Melhem H, et al.
Cell Rep
. 2020 Aug;
32(5):107979.
PMID: 32755573
Single-nucleotide polymorphisms in the gene encoding G protein-coupled receptor 35 (GPR35) are associated with increased risk of inflammatory bowel disease. However, the mechanisms by which GPR35 modulates intestinal immune homeostasis...
9.
Zaugg J, Melhem H, Huang X, Wegner M, Baumann M, Surbek D, et al.
FASEB J
. 2020 Apr;
34(6):7311-7329.
PMID: 32285992
Clinical studies suggest that pregnant women with elevated iron levels are more vulnerable to develop gestational diabetes mellitus (GDM), but the causes and underlying mechanisms are unknown. We hypothesized that...
10.
Wuggenig P, Kaya B, Melhem H, Ayata C, Hruz P, Sayan A, et al.
Commun Biol
. 2020 Mar;
3(1):130.
PMID: 32188932
Comprehensive development is critical for gut macrophages being essential for the intestinal immune system. However, the underlying mechanisms of macrophage development in the colon remain elusive. To investigate the function...