Hasim Zecic
Overview
Explore the profile of Hasim Zecic including associated specialties, affiliations and a list of published articles.
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Snapshot
Snapshot
Articles
3
Citations
48
Followers
0
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Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
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Published In
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Recent Articles
1.
Lou Y, Han X, Kuglstatter A, Kondru R, Sweeney Z, Soth M, et al.
J Med Chem
. 2014 Apr;
58(1):512-6.
PMID: 24712864
Structure-based drug design was used to guide the optimization of a series of selective BTK inhibitors as potential treatments for Rheumatoid arthritis. Highlights include the introduction of a benzyl alcohol...
2.
Soth M, Abbot S, Abubakari A, Arora N, Arzeno H, Billedeau R, et al.
Bioorg Med Chem Lett
. 2011 Apr;
21(11):3452-6.
PMID: 21515047
Learnings from previous Roche p38-selective inhibitors were applied to a new fragment hit, which was optimized to a potent, exquisitely selective preclinical lead with a good pharmacokinetic profile.
3.
Goldstein D, Soth M, Gabriel T, Dewdney N, Kuglstatter A, Arzeno H, et al.
J Med Chem
. 2011 Mar;
54(7):2255-65.
PMID: 21375264
The development of a new series of p38α inhibitors resulted in the identification of two clinical candidates, one of which was advanced into a phase 2 clinical study for rheumatoid...