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Harrison W Smith

Explore the profile of Harrison W Smith including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
1.
Lee E, Smith H, Wang Y, Ihn S, Scalize de Oliveira L, Kejiou N, et al.
Life Sci Alliance . 2024 Dec; 8(2). PMID: 39626965
In humans, misprocessed mRNAs containing intact 5' Splice Site (5'SS) motifs are nuclear retained and targeted for decay by ZFC3H1, a component of the Poly(A) Exosome Targeting complex, and U1-70K,...
2.
Lee E, Smith H, Wolf E, Guvenek A, Wang Y, Emili A, et al.
RNA . 2022 Mar; 28(6):878-894. PMID: 35351812
Quality control of mRNA represents an important regulatory mechanism for gene expression in eukaryotes. One component of this quality control is the nuclear retention and decay of misprocessed RNAs. Previously,...
3.
Shen Q, Wang Y, Truong M, Mahadevan K, Wu J, Zhang H, et al.
PLoS Genet . 2021 Feb; 17(2):e1009378. PMID: 33600493
Mutations in RanBP2 (also known as Nup358), one of the main components of the cytoplasmic filaments of the nuclear pore complex, contribute to the overproduction of acute necrotizing encephalopathy (ANE1)-associated...
4.
Lee E, Wolf E, Ihn S, Smith H, Emili A, Palazzo A
Nucleic Acids Res . 2020 Oct; 48(20):11645-11663. PMID: 33091126
While splicing has been shown to enhance nuclear export, it has remained unclear whether mRNAs generated from intronless genes use specific machinery to promote their export. Here, we investigate the...