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Harris Bernstein

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Articles 41
Citations 1283
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Recent Articles
1.
Bernstein H, Bernstein C
Exp Biol Med (Maywood) . 2022 Nov; 248(1):79-89. PMID: 36408538
Colon cancer incidence is associated with a high-fat diet. Such a diet is linked to elevated levels of bile acids in the gastrointestinal system and the circulation. Secondary bile acids...
2.
Bernstein H, Bernstein C, Michod R
Infect Genet Evol . 2017 Nov; 57:8-25. PMID: 29111273
We review the sexual processes common in pathogenic microorganisms and assess the primary adaptive benefit of such processes. The pathogenic microorganisms considered include bacteria, microbial eukaryotes, and viruses. The sexual...
3.
Bernstein C, Bernstein H
World J Gastrointest Oncol . 2015 May; 7(5):30-46. PMID: 25987950
Deficiencies in DNA repair due to inherited germ-line mutations in DNA repair genes cause increased risk of gastrointestinal (GI) cancer. In sporadic GI cancers, mutations in DNA repair genes are...
4.
Prasad A, Prasad S, Nguyen H, Facista A, Lewis C, Zaitlin B, et al.
World J Gastrointest Oncol . 2014 Jul; 6(7):225-43. PMID: 25024814
Aim: To investigate the close parallels between our novel diet-related mouse model of colon cancer and human colon cancer. Methods: Twenty-two wild-type female mice (ages 6-8 wk) were fed the...
5.
Bernstein C, Nfonsam V, Prasad A, Bernstein H
World J Gastrointest Oncol . 2013 May; 5(3):43-9. PMID: 23671730
A field defect is a field of pre-malignant tissue in which a new cancer is likely to arise. Field defects often appear to be histologically normal under the microscope. Recent...
6.
Facista A, Nguyen H, Lewis C, Prasad A, Ramsey L, Zaitlin B, et al.
Genome Integr . 2012 Apr; 3(1):3. PMID: 22494821
Background: Cancers often arise within an area of cells (e.g. an epithelial patch) that is predisposed to the development of cancer, i.e. a "field of cancerization" or "field defect." Sporadic...
7.
Payne C, Holubec H, Crowley-Skillicorn C, Nguyen H, Bernstein H, Wilcox G, et al.
Clin Exp Gastroenterol . 2011 Dec; 4:239-53. PMID: 22162927
Increased maspin expression in the colon is related to colon cancer risk and patient survival. Maspin is induced by the hydrophobic bile acid, deoxycholate (DOC), which is an endogenous carcinogen...
8.
Chen H, Bernstein H, Ranganathan P, Schluter S
Dev Comp Immunol . 2011 Sep; 37(1):176-83. PMID: 21925537
In a recent publication we demonstrated that somatic hypermutation occurs in the V region of the TCR γ gene of the sandbar shark (Carcharhinus plumbeus). We hypothesize that similar mechanisms...
9.
Payne C, Crowley-Skillicorn C, Bernstein C, Holubec H, Bernstein H
Clin Exp Gastroenterol . 2011 Jul; 4:75-119. PMID: 21753893
Chromosomal instability is a major pathway of sporadic colon carcinogenesis. Chromosome arm 1p appears to be one of the "hot spots" in the non-neoplastic mucosa that, when deleted, is associated...
10.
Payne C, Bernstein C, Dvorak K, Bernstein H
Clin Exp Gastroenterol . 2011 Jun; 1:19-47. PMID: 21677822
Sporadic colon cancer is caused predominantly by dietary factors. We have selected bile acids as a focus of this review since high levels of hydrophobic bile acids accompany a Western-style...