Harriet McHale-Owen
Overview
Explore the profile of Harriet McHale-Owen including associated specialties, affiliations and a list of published articles.
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5
Citations
36
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Recent Articles
1.
Signoria I, Zwartkruis M, Geerlofs L, Perenthaler E, Faller K, James R, et al.
Mol Ther Methods Clin Dev
. 2024 Dec;
32(4):101379.
PMID: 39655308
The availability of three therapies for the neuromuscular disease spinal muscular atrophy (SMA) highlights the need to match patients to the optimal treatment. Two of these treatments (nusinersen and risdiplam)...
2.
McHale-Owen H, Bate C
Biochim Biophys Acta Mol Basis Dis
. 2017 Dec;
1864(3):649-659.
PMID: 29247837
The production of amyloid-β (Aβ) is the key factor driving pathogenesis in Alzheimer's disease (AD). Increasing concentrations of Aβ within the brain cause synapse degeneration and the dementia that is...
3.
Nolan W, McHale-Owen H, Bate C
Biochem J
. 2017 Jul;
474(17):3045-3058.
PMID: 28729427
The production of amyloid-β (Aβ) is a key factor driving pathogenesis in Alzheimer's disease (AD). Increasing concentrations of soluble Aβ oligomers within the brain lead to synapse degeneration and the...
4.
Bate C, Nolan W, McHale-Owen H, Williams A
J Biol Chem
. 2016 Jun;
291(33):17093-101.
PMID: 27325697
Although the cellular prion protein (PrP(C)) is concentrated at synapses, the factors that target PrP(C) to synapses are not understood. Here we demonstrate that exogenous PrP(C) was rapidly targeted to...
5.
Osborne C, West E, Nolan W, McHale-Owen H, Williams A, Bate C
Neuropharmacology
. 2015 Oct;
101:225-36.
PMID: 26432105
Alzheimer's disease is associated with the accumulation within the brain of amyloid-β (Aβ) peptides that damage synapses and affect memory acquisition. This process can be modelled by observing the effects...