Harold Swerdlow
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Explore the profile of Harold Swerdlow including associated specialties, affiliations and a list of published articles.
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18
Citations
5605
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Recent Articles
1.
Ruf-Zamojski F, Ge Y, Nair V, Zamojski M, Pincas H, Toufaily C, et al.
Nucleic Acids Res
. 2018 Oct;
46(21):11370-11380.
PMID: 30357357
Immediate-early response genes (IEGs) are rapidly and transiently induced following an extracellular signal. Elucidating the IEG response patterns in single cells (SCs) requires assaying large numbers of timed samples at...
2.
Stoeckius M, Hafemeister C, Stephenson W, Houck-Loomis B, Chattopadhyay P, Swerdlow H, et al.
Nat Methods
. 2017 Aug;
14(9):865-868.
PMID: 28759029
High-throughput single-cell RNA sequencing has transformed our understanding of complex cell populations, but it does not provide phenotypic information such as cell-surface protein levels. Here, we describe cellular indexing of...
3.
Bronner I, Quail M, Turner D, Swerdlow H
Curr Protoc Hum Genet
. 2015 Aug;
80:18.2.1-42.
PMID: 26270174
In this unit, we describe a set of improvements that have been made to the standard Illumina protocols to make the sequencing process more reliable in a high-throughput environment, reduce...
4.
Smith M, Campino S, Gu Y, Clark T, Otto T, Maslen G, et al.
Open Genomics J
. 2013 Nov;
5.
PMID: 24273626
Studies on DNA from pathogenic organisms, within clinical samples, are often complicated by the presence of large amounts of host, e.g., human DNA. Isolation of pathogen DNA from these samples...
5.
Wang Q, Xue Y, Zhang Y, Long Q, Asan , Yang F, et al.
Am J Hum Genet
. 2013 Jan;
92(2):301-6.
PMID: 23352258
A single Mendelian trait has been mapped to the human Y chromosome: Y-linked hearing impairment. The molecular basis of this disorder is unknown. Here, we report the detailed characterization of...
6.
Coupland P, Chandra T, Quail M, Reik W, Swerdlow H
Biotechniques
. 2012 Dec;
53(6):365-72.
PMID: 23227987
We have developed a sequencing method on the Pacific Biosciences RS sequencer (the PacBio) for small DNA molecules that avoids the need for a standard library preparation. To date this...
7.
Quail M, Gu Y, Swerdlow H, Mayho M
Electrophoresis
. 2012 Nov;
33(23):3521-8.
PMID: 23147856
Size selection can be a critical step in preparation of next-generation sequencing libraries. Traditional methods employing gel electrophoresis lack reproducibility, are labour intensive, do not scale well and employ hazardous...
8.
Hu M, Ayub Q, Guerra-Assuncao J, Long Q, Ning Z, Huang N, et al.
Hum Genet
. 2011 Nov;
131(5):665-74.
PMID: 22057783
We have investigated whether regions of the genome showing signs of positive selection in scans based on haplotype structure also show evidence of positive selection when sequence-based tests are applied,...
9.
Stephens P, Greenman C, Fu B, Yang F, Bignell G, Mudie L, et al.
Cell
. 2011 Jan;
144(1):27-40.
PMID: 21215367
Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time. Using next-generation sequencing, we characterize a phenomenon, which we term chromothripsis, whereby...
10.
Campbell P, Yachida S, Mudie L, Stephens P, Pleasance E, Stebbings L, et al.
Nature
. 2010 Oct;
467(7319):1109-13.
PMID: 20981101
Pancreatic cancer is an aggressive malignancy with a five-year mortality of 97-98%, usually due to widespread metastatic disease. Previous studies indicate that this disease has a complex genomic landscape, with...