Harold S Sacks
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Explore the profile of Harold S Sacks including associated specialties, affiliations and a list of published articles.
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23
Citations
1049
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Recent Articles
1.
Mori S, Beyer R, Bernardes de Souza B, Sorg J, Hoover D, Sacks H, et al.
PLoS One
. 2023 Oct;
18(10):e0290455.
PMID: 37792692
Background: The supraclavicular fossa is the dominant location for human brown adipose tissue (BAT). Activation of BAT promotes non-shivering thermogenesis by utilization of glucose and free fatty acids and has...
2.
Jurrissen T, Ramirez-Perez F, Cabral-Amador F, Soares R, Pettit-Mee R, Betancourt-Cortes E, et al.
Am J Physiol Heart Circ Physiol
. 2022 Sep;
323(5):H879-H891.
PMID: 36083795
Adropin is a peptide largely secreted by the liver and known to regulate energy homeostasis; however, it also exerts cardiovascular effects. Herein, we tested the hypothesis that low circulating levels...
3.
Acin-Perez R, Petcherski A, Veliova M, Benador I, Assali E, Colleluori G, et al.
Redox Biol
. 2021 Aug;
46:102087.
PMID: 34411987
Beige adipocyte mitochondria contribute to thermogenesis by uncoupling and by ATP-consuming futile cycles. Since uncoupling may inhibit ATP synthesis, it is expected that expenditure through ATP synthesis is segregated to...
4.
Winn N, Acin-Perez R, Woodford M, Hansen S, Haney M, Ayedun L, et al.
Diabetes
. 2019 Mar;
68(9):1717-1729.
PMID: 30862679
The prevailing dogma is that thermogenic brown adipose tissue (BAT) contributes to improvements in glucose homeostasis in obesogenic animal models, though much of the evidence supporting this premise is from...
5.
Clookey S, Welly R, Zidon T, Gastecki M, Woodford M, Grunewald Z, et al.
J Endocrinol
. 2018 Aug;
239(2):107-120.
PMID: 30089681
Premenopausal females are protected against adipose tissue inflammation and insulin resistance, until loss of ovarian hormone production (e.g., menopause). There is some evidence that females have greater brown adipose tissue...
6.
Grunewald Z, Winn N, Gastecki M, Woodford M, Ball J, Hansen S, et al.
Am J Physiol Regul Integr Comp Physiol
. 2018 Jan;
314(4):R584-R597.
PMID: 29351429
Brown adipose tissue (BAT) is considered protective against obesity and related cardiometabolic dysfunction. Indeed, activation of BAT improves glucose homeostasis and attenuates cardiovascular disease development. However, whether a reduction in...
7.
Winn N, Grunewald Z, Gastecki M, Woodford M, Welly R, Clookey S, et al.
Am J Physiol Endocrinol Metab
. 2017 Jun;
313(4):E402-E412.
PMID: 28655717
Females are typically more insulin sensitive than males, which may be partly attributed to greater brown adipose tissue (BAT) activity and uncoupling protein 1 (UCP1) content. Accordingly, we tested the...
8.
McKenney-Drake M, Rodenbeck S, Bruning R, Kole A, Yancey K, Alloosh M, et al.
Ann Thorac Surg
. 2017 Feb;
103(5):1622-1630.
PMID: 28223054
Background: Pericoronary epicardial adipose tissue (cEAT) serves as a metabolic and paracrine organ that contributes to inflammation and is associated with macrovascular coronary artery disease (CAD) development. Although there is...
9.
Winn N, Vieira-Potter V, Gastecki M, Welly R, Scroggins R, Zidon T, et al.
Am J Physiol Regul Integr Comp Physiol
. 2016 Nov;
312(1):R74-R84.
PMID: 27881400
We tested the hypothesis that female mice null for uncoupling protein 1 (UCP1) would have increased susceptibility to Western diet-induced "whitening" of brown adipose tissue (AT) and glucose intolerance. Six-week-old...
10.
Aldiss P, Davies G, Woods R, Budge H, Sacks H, Symonds M
Int J Cardiol
. 2016 Nov;
228:265-274.
PMID: 27865196
Excess visceral adiposity, in particular that located adjacent to the heart and coronary arteries is associated with increased cardiovascular risk. In the pathophysiological state, dysfunctional adipose tissue secretes an array...