Hark Kyun Kim
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Explore the profile of Hark Kyun Kim including associated specialties, affiliations and a list of published articles.
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83
Citations
1820
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Recent Articles
1.
Kim J, Jun J, Lee J, Park S, Kim E, Hwang S, et al.
Metabolism
. 2024 Dec;
164:156108.
PMID: 39689826
Background: Diabetic retinopathy (DR), a major blindness cause in developed countries, is intricately linked to diabetes management and its duration. Here, we demonstrate that HDAC6 mediates NLRP3 inflammasome activation under...
2.
Sul J, Shin S, Kim H, Han J, Kim J, Son S, et al.
J Extracell Vesicles
. 2024 Dec;
13(12):e70018.
PMID: 39641313
The application of extracellular vesicles (EVs) as vehicles for anti-Parkinson's agents represents a significant advance, yet their clinical translation is hampered by challenges in efficient brain delivery and complex blood-brain...
3.
Han J, Sul J, Lee J, Kim E, Kim H, Chae M, et al.
Sci Transl Med
. 2024 Aug;
16(759):eadi4830.
PMID: 39110781
Effective intracellular delivery of therapeutic proteins can potentially treat a wide array of diseases. However, efficient delivery of functional proteins across the cell membrane remains challenging. Exosomes are nanosized vesicles...
4.
Kang Y, Kim H, Yook J, Park Y, Lee J, Kim Y, et al.
J Clin Oncol
. 2024 Jul;
42(25):2961-2965.
PMID: 38996201
JCO The phase III PRODIGY study demonstrated that neoadjuvant chemotherapy with docetaxel, oxaliplatin, and S-1 (DOS) followed by surgery and adjuvant S-1 chemotherapy (CSC) improved progression-free survival (PFS) compared with...
5.
Kim E, Kim H, Sul J, Lee J, Baek S, Cho Y, et al.
Biomol Ther (Seoul)
. 2024 Jun;
32(4):432-441.
PMID: 38835111
Systemic sclerosis is an autoimmune disease characterized by inflammatory reactions and fibrosis. Myofibroblasts are considered therapeutic targets for preventing and reversing the pathogenesis of fibrosis in systemic sclerosis. Although the...
6.
Kim J, Kratz A, Chen S, Sheng J, Kim H, Zhang L, et al.
Sci Adv
. 2024 May;
10(18):eadg8771.
PMID: 38691600
To facilitate the interrogation of protein function at scale, we have developed high-throughput insertion of tags across the genome (HITAG). HITAG enables users to rapidly produce libraries of cells, each...
7.
Eom S, Choi W, Eom B, Park S, Kim S, Kim Y, et al.
J Gastric Cancer
. 2022 Apr;
22(1):3-23.
PMID: 35425651
Countries differ in their treatment expertise and research results regarding gastric cancer; hence, treatment guidelines are diverse based on evidence and medical situations. A comprehensive and comparative review of each...
8.
Park J, Seo M, Cho K, Kook M, Jeong J, Roh S, et al.
Cancer Med
. 2022 Mar;
11(9):1925-1936.
PMID: 35274815
Background: Smad4 and p53 mutations are the most common mutations in human colorectal cancers (CRCs). We evaluated whether and how they are synergistic in intestinal carcinogenesis using novel autochthonous mouse...
9.
Kim H, Cho J, Kim E, Kim J, Yang J, Kim K, et al.
J Extracell Vesicles
. 2022 Jan;
11(1):e12179.
PMID: 34982509
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry is mediated by the interaction of the viral spike (S) protein with angiotensin-converting enzyme 2 (ACE2) on the host cell surface. Although...
10.
Khang R, Jo A, Kang H, Kim H, Kwag E, Lee J, et al.
Sci Rep
. 2021 Nov;
11(1):22745.
PMID: 34815492
Although Krüppel-associated box domain-containing zinc-finger proteins (K-ZNFs) may be associated with sophisticated gene regulation in higher organisms, the physiological functions of most K-ZNFs remain unknown. The Zfp212 protein was highly...