Haoning Howard Cen
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Explore the profile of Haoning Howard Cen including associated specialties, affiliations and a list of published articles.
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11
Citations
81
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Recent Articles
1.
Atser M, Wenyonu C, Rowe E, Leung C, Cen H, Queathem E, et al.
J Biol Chem
. 2025 Mar;
:108398.
PMID: 40074083
Pyruvate dehydrogenase kinase (PDK) 1 is one of four isozymes that inhibit the oxidative decarboxylation of pyruvate to acetyl-CoA via pyruvate dehydrogenase. PDK activity is elevated in fasting or starvation...
2.
Atser M, Wenyonu C, Rowe E, Leung C, Cen H, Queathem E, et al.
bioRxiv
. 2024 Oct;
PMID: 39464135
Pyruvate dehydrogenase kinase (PDK) 1 is one of four isozymes that inhibit the oxidative decarboxylation of pyruvate to acetyl-CoA via pyruvate dehydrogenase. PDK activity is elevated in fasting or starvation...
3.
Zhao J, Liang S, Cen H, Li Y, Baker R, Ruprai B, et al.
Nat Commun
. 2024 Jul;
15(1):5894.
PMID: 39003281
Remarkable advances in protocol development have been achieved to manufacture insulin-secreting islets from human pluripotent stem cells (hPSCs). Distinct from current approaches, we devised a tunable strategy to generate islet...
4.
Kolic J, Sun W, Cen H, Ewald J, Rogalski J, Sasaki S, et al.
Cell Metab
. 2024 Jul;
36(7):1619-1633.e5.
PMID: 38959864
Population-level variation and mechanisms behind insulin secretion in response to carbohydrate, protein, and fat remain uncharacterized. We defined prototypical insulin secretion responses to three macronutrients in islets from 140 cadaveric...
5.
Durrer C, Islam H, Cen H, Garzon M, Lyu X, McKelvey S, et al.
Nutr Metab (Lond)
. 2024 May;
21(1):29.
PMID: 38797835
Background: Substantial weight loss in people living with type 2 diabetes (T2D) can reduce the need for glucose-lowering medications while concurrently lowering glycemia below the diagnostic threshold for the disease....
6.
Kolic J, Sun W, Cen H, Ewald J, Rogalski J, Sasaki S, et al.
medRxiv
. 2024 Mar;
PMID: 38496562
One-sentence Summary: Deep phenotyping and multi-omics reveal individualized nutrient-specific insulin secretion propensity.
7.
Zhang A, Xia Y, Lin J, Chu K, Wang W, Ruiter T, et al.
Cell Metab
. 2023 Nov;
35(12):2119-2135.e5.
PMID: 37913768
The rising pancreatic cancer incidence due to obesity and type 2 diabetes is closely tied to hyperinsulinemia, an independent cancer risk factor. Previous studies demonstrated reducing insulin production suppressed pancreatic...
8.
Stokes T, Cen H, Kapranov P, Gallagher I, Pitsillides A, Volmar C, et al.
Adv Genet (Hoboken)
. 2023 Jun;
4(2):2200024.
PMID: 37288167
Sequencing the human genome empowers translational medicine, facilitating transcriptome-wide molecular diagnosis, pathway biology, and drug repositioning. Initially, microarrays are used to study the bulk transcriptome; but now short-read RNA sequencing...
9.
Lee C, Zhai Y, Shang R, Wong T, Mattison A, Cen H, et al.
J Am Heart Assoc
. 2022 Nov;
11(23):e027958.
PMID: 36416172
Background Lipoprotein lipase (LPL)-derived fatty acid is a major source of energy for cardiac contraction. Synthesized in cardiomyocytes, LPL requires translocation to the vascular lumen for hydrolysis of lipoprotein triglyceride,...
10.
Skovso S, Panzhinskiy E, Kolic J, Cen H, Dionne D, Dai X, et al.
Nat Commun
. 2022 Feb;
13(1):735.
PMID: 35136059
Insulin receptor (Insr) protein is present at higher levels in pancreatic β-cells than in most other tissues, but the consequences of β-cell insulin resistance remain enigmatic. Here, we use an...