Hans Rudolf Bosshard
Overview
Explore the profile of Hans Rudolf Bosshard including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
265
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Recent Articles
1.
Devi V, Sprecher C, Hunziker P, Mittl P, Bosshard H, Jelesarov I
Biochemistry
. 2006 Feb;
45(6):1599-607.
PMID: 16460007
Helicobacter pylori cysteine-rich proteins (Hcps) are disulfide-containing repeat proteins. The repeating unit is a 36-residue, disulfide-bridged, helix-loop-helix motif. We use the protein HcpB, which has four repeats and four disulfide...
2.
Milev S, Bosshard H, Jelesarov I
Biochemistry
. 2005 Jan;
44(1):285-93.
PMID: 15628870
The effect of low molecular-weight compounds on the equilibrium constant K(A) can be used to explore the energetics and molecular mechanism of protein-DNA interactions. Here we use the complex composed...
3.
Devi V, Binz H, Stumpp M, Pluckthun A, Bosshard H, Jelesarov I
Protein Sci
. 2004 Oct;
13(11):2864-70.
PMID: 15498935
Ankyrin repeats (AR) are 33-residue motifs containing a beta-turn, followed by two alpha-helices connected by a loop. AR occur in tandem arrangements and stack side-by-side to form elongated domains involved...
4.
Marti D, Bosshard H
Biochemistry
. 2004 Sep;
43(39):12436-47.
PMID: 15449933
The pH-dependent stability of a protein is strongly affected by electrostatic interactions between ionizable residues in the folded as well as unfolded state. Here we characterize the individual contributions of...
5.
Bosshard H, Marti D, Jelesarov I
J Mol Recognit
. 2004 Feb;
17(1):1-16.
PMID: 14872533
Salt bridges in proteins are bonds between oppositely charged residues that are sufficiently close to each other to experience electrostatic attraction. They contribute to protein structure and to the specificity...
6.
Marti D, Bjelic S, Lu M, Bosshard H, Jelesarov I
J Mol Biol
. 2004 Jan;
336(1):1-8.
PMID: 14741199
Human (HIV-1) and simian (SIV) immunodeficiency virus fusion with the host cell is promoted by the receptor-triggered refolding of the gp41 envelope protein into a stable trimer-of-hairpins structure that brings...
7.
Cranz S, Berger C, Baici A, Jelesarov I, Bosshard H
Biochemistry
. 2004 Jan;
43(3):718-27.
PMID: 14730976
Basic leucine zipper (bZIP) transcription factors are dimeric proteins that recognize dyadic and mostly palindromic DNA sites. Dimerization of bZIP transcription factor GCN4 is linked to the folding of its...
8.
Marti D, Bosshard H
J Mol Biol
. 2003 Jul;
330(3):621-37.
PMID: 12842476
Electrostatic interactions play a complex role in stabilizing proteins. Here, we present a rigorous thermodynamic analysis of the contribution of individual Glu and His residues to the relative pH-dependent stability...
9.
Milev S, Gorfe A, Karshikoff A, Clubb R, Bosshard H, Jelesarov I
Biochemistry
. 2003 Mar;
42(12):3492-502.
PMID: 12653553
Sequence-specific DNA recognition by bacterial integrase Tn916 involves structural rearrangements of both the protein and the DNA duplex. Energetic contributions from changes of conformation, thermal motions and soft vibrational modi...
10.
Milev S, Gorfe A, Karshikoff A, Clubb R, Bosshard H, Jelesarov I
Biochemistry
. 2003 Mar;
42(12):3481-91.
PMID: 12653552
The DNA binding domain of the transposon Tn916 integrase (INT-DBD) binds to its DNA target site by positioning the face of a three-stranded antiparallel beta-sheet within the major groove. Binding...