Hans C Hurlimann
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Explore the profile of Hans C Hurlimann including associated specialties, affiliations and a list of published articles.
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5
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48
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Recent Articles
1.
Gebauer M, Hurlimann H, Behrens M, Wolff T, Behrens S
Vaccine
. 2019 Aug;
37(37):5578-5587.
PMID: 31399274
Here we report on new subunit vaccines based on recombinant yeast of the type Kluyveromyces lactis (K. lactis), which protect mice from a lethal influenza A virus infection. Applying a...
2.
Douillet D, Pinson B, Ceschin J, Hurlimann H, Saint-Marc C, Laporte D, et al.
J Biol Chem
. 2018 Nov;
294(3):805-815.
PMID: 30478173
5-Aminoimidazole-4-carboxamide 1-β-d-ribofuranoside (AICAR, or acadesine) is a precursor of the monophosphate derivative 5-amino-4-imidazole carboxamide ribonucleoside 5'-phosphate (ZMP), an intermediate in purine biosynthesis. AICAR proved to have promising anti-proliferative properties, although...
3.
Albrecht D, Hurlimann H, Ceschin J, Saint-Marc C, Pinson B, Daignan-Fornier B
Curr Genet
. 2018 May;
64(6):1275-1286.
PMID: 29721631
AICAR is the precursor of ZMP, a metabolite with antiproliferative properties in yeast and human. We aim at understanding how AICAR (and its active form ZMP) affects essential cellular processes....
4.
Saint-Marc C, Hurlimann H, Daignan-Fornier B, Pinson B
Curr Genet
. 2015 Apr;
61(4):633-40.
PMID: 25893566
Previous genetic analyses showed phenotypic interactions between 5-amino-4-imidazole carboxamide ribonucleotide 5'-phosphate (AICAR) produced from the purine and histidine pathways and methionine biosynthesis. Here, we revisited the effect of AICAR on...
5.
Hurlimann H, Laloo B, Simon-Kayser B, Saint-Marc C, Coulpier F, Lemoine S, et al.
J Biol Chem
. 2011 Jul;
286(35):30994-31002.
PMID: 21757731
5-Amino-4-imidazolecarboxamide ribonucleotide 5'-phosphate (AICAR) is a monophosphate metabolic intermediate of the de novo purine synthesis pathway that has highly promising metabolic and antiproliferative properties. Yeast mutants unable to metabolize AICAR...