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Hans Bouwmeester

Explore the profile of Hans Bouwmeester including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 79
Citations 1883
Followers 0
Related Specialties
Toxicology
Biotechnology
Chemistry
Top 10 Co-Authors
Meike van der Zande
Ivonne M C M Rietjens
Hans J P Marvin
Ruud J B Peters
Laura de Haan
Evelien Kramer
Nynke I Kramer
Ad A C M Peijnenburg
Peter J M Hendriksen
Wouter Bakker
Published In
Nanotoxicology
Arch Toxicol
Environ Sci Technol
ALTEX
J Agric Food Chem
Affiliations
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Recent Articles
1.
Correction to "Development of a Generic Physiologically Based Kinetic Model for the Prediction of Internal Exposure to Organophosphate Pesticides"
Moerenhout T, Chen J, Bouwmeester H, Rietjens I, Kramer N
Environ Sci Technol . 2024 Nov; 58(46):20761. PMID: 39494802
No abstract available.
2.
Development of a Generic Physiologically Based Kinetic Model for the Prediction of Internal Exposure to Organophosphate Pesticides
Moerenhout T, Chen J, Bouwmeester H, Rietjens I, Kramer N
Environ Sci Technol . 2024 Oct; 58(42):18834-18845. PMID: 39374537
Since their introduction into agriculture, the toxicity of organophosphate (OP) pesticides has been widely studied in animal models. However, next generation risk assessment (NGRA) intends to maximize the use of...
3.
Elevated risk of adverse effects from foodborne contaminants and drugs in inflammatory bowel disease: a review
Walraven T, Busch M, Wang J, Donkers J, Duijvestein M, van de Steeg E, et al.
Arch Toxicol . 2024 Sep; 98(11):3519-3541. PMID: 39249550
The global burden of Inflammatory bowel disease (IBD) has been rising over the last decades. IBD is an intestinal disorder with a complex and largely unknown etiology. The disease is...
4.
Artificial intelligence-based data extraction for next generation risk assessment: Is fine-tuning of a large language model worth the effort?
Sonnenburg A, van der Lugt B, Rehn J, Wittkowski P, Bech K, Padberg F, et al.
Toxicology . 2024 Aug; 508:153933. PMID: 39181527
To underpin scientific evaluations of chemical risks, agencies such as the European Food Safety Authority (EFSA) heavily rely on the outcome of systematic reviews, which currently require extensive manual effort....
5.
Physiologically based Kinetic Modeling-Facilitated Quantitative to Extrapolation to Predict the Effects of Aloe-Emodin in Rats and Humans
Ren Q, Chen J, Wesseling S, Bouwmeester H, Rietjens I
J Agric Food Chem . 2024 Jul; 72(29):16163-16176. PMID: 38980703
Aloe-emodin, a natural hydroxyanthraquinone, exerts both adverse and protective effects. This study aimed at investigating these potential effects of aloe-emodin in humans upon the use of food supplements and herbal...
6.
The in vitro gastrointestinal digestion-associated protein corona of polystyrene nano- and microplastics increases their uptake by human THP-1-derived macrophages
Brouwer H, Porbahaie M, Boeren S, Busch M, Bouwmeester H
Part Fibre Toxicol . 2024 Feb; 21(1):4. PMID: 38311718
Background: Micro- and nanoplastics (MNPs) represent one of the most widespread environmental pollutants of the twenty-first century to which all humans are orally exposed. Upon ingestion, MNPs pass harsh biochemical...
7.
Use of Physiologically Based Kinetic Modeling to Predict Deoxynivalenol Metabolism and Its Role in Intestinal Inflammation and Bile Acid Kinetics in Humans
Wang J, de Bruijn V, Rietjens I, Kramer N, Bouwmeester H
J Agric Food Chem . 2023 Dec; 72(1):761-772. PMID: 38131302
Current points of departure used to derive health-based guidance values for deoxynivalenol (DON) are based on studies in laboratory animals. Here, an animal-free testing approach was adopted in which a...
8.
Acetylcholinesterase Inhibition in Rats and Humans Following Acute Fenitrothion Exposure Predicted by Physiologically Based Kinetic Modeling-Facilitated Quantitative to Extrapolation
Chen J, Zhao S, Wesseling S, Kramer N, Rietjens I, Bouwmeester H
Environ Sci Technol . 2023 Nov; 57(49):20521-20531. PMID: 38008925
Worldwide use of organophosphate pesticides as agricultural chemicals aims to maintain a stable food supply, while their toxicity remains a major public health concern. A common mechanism of acute neurotoxicity...
9.
Deoxynivalenol increases pro-inflammatory cytokine secretion and reduces primary bile acid transport in an inflamed intestinal in vitro co-culture model
Wang J, Bakker W, de Haan L, Bouwmeester H
Food Res Int . 2023 Oct; 173(Pt 1):113323. PMID: 37803634
The fungal secondary metabolite deoxynivalenol (DON) that can contaminate cereal-based food products not only induces inflammation but also reduces bile acid absorption by a healthy human intestine. Bile acid malabsorption...
10.
On the Role of ROS and Glutathione in the Mode of Action Underlying Nrf2 Activation by the Hydroxyanthraquinone Purpurin
Ren Q, Bakker W, Wesseling S, Bouwmeester H, Rietjens I
Antioxidants (Basel) . 2023 Aug; 12(8). PMID: 37627539
Purpurin is a major anthraquinone present in the roots of (madder). Purpurin is known to activate Nrf2 (Nuclear transcription factor erythroid 2-related factor 2) EpRE (electrophile responsive element) mediated gene...