Hans-Jurgen Pietzsch
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Explore the profile of Hans-Jurgen Pietzsch including associated specialties, affiliations and a list of published articles.
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71
Citations
502
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Recent Articles
1.
Urbanovsky P, David T, Hlinova V, Kubicek V, Pietzsch H, Hermann P
Org Biomol Chem
. 2024 Nov;
23(3):699-720.
PMID: 39611221
Copper radioisotopes can be used for imaging as well as for therapy and, thus, can form ideal theranostic pairs. The Cu(II) complexes of cross-bridged cyclam (cb-cyclam) derivatives are considered to...
2.
Sihver W, Walther M, Ullrich M, Nitt-Weber A, Bohme J, Reissig F, et al.
Bioconjug Chem
. 2024 Aug;
35(9):1402-1416.
PMID: 39185789
The AlF-labeling approach offers a one-step access to radiofluorinated biomolecules by mimicking the labeling process for radiometals. Although these labeling conditions are considered to be mild compared to classic radiofluorinations,...
3.
Striese F, Neuber C, Grassel S, Arndt C, Ullrich M, Steinbach J, et al.
Int J Mol Sci
. 2023 Jun;
24(11).
PMID: 37298374
Prostate specific membrane antigen (PSMA) is an excellent target for imaging and treatment of prostate carcinoma (PCa). Unfortunately, not all PCa cells express PSMA. Therefore, alternative theranostic targets are required....
4.
Bruhlmann S, Walther M, Kreller M, Reissig F, Pietzsch H, Kniess T, et al.
Pharmaceuticals (Basel)
. 2023 Jun;
16(2).
PMID: 37259458
Theranostic matched pairs of radionuclides have aroused interest during the last couple of years, and in that sense, copper is one element that has a lot to offer, and although...
5.
Schlesinger M, Jentschel C, Pietzsch H, Kopka K, Mamat C
Dalton Trans
. 2023 Feb;
52(10):3024-3032.
PMID: 36779384
Click chemistry, in particular copper-free click reactions, has gained growing interest for radiolabelling purposes in the field of radiopharmaceutical sciences. [Tc][Tc(CO)(HO)] works as an excellent starting complex for the radiolabelling...
6.
Heerwig A, Kick A, Sommerfeld P, Eimermacher S, Hartung F, Laube M, et al.
Int J Mol Sci
. 2023 Jan;
24(2).
PMID: 36675164
In addition to the classic functions of proteins, such as acting as a biocatalyst or binding partner, the conformational states of proteins and their remodeling upon stimulation need to be...
7.
Brandt F, Ullrich M, Wodtke J, Kopka K, Bachmann M, Loser R, et al.
J Med Chem
. 2023 Jan;
66(1):516-537.
PMID: 36595224
The applicability of radioligands for targeted endoradionuclide therapy is limited due to radiation-induced toxicity to healthy tissues, in particular to the kidneys as primary organs of elimination. The targeting of...
8.
Reissig F, Zarschler K, Novy Z, Petrik M, Bendova K, Kurfurstova D, et al.
Theranostics
. 2022 Nov;
12(17):7203-7215.
PMID: 36438496
Small Ac-labeled prostate-specific membrane antigen (PSMA)-targeted radioconjugates have been described for targeted alpha therapy of metastatic castration-resistant prostate cancer. Transient binding to serum albumin as a highly abundant, inherent transport...
9.
Bruhlmann S, Kreller M, Pietzsch H, Kopka K, Mamat C, Walther M, et al.
Pharmaceuticals (Basel)
. 2022 Oct;
15(10).
PMID: 36297279
Targeted Alpha Therapy is a research field of highest interest in specialized radionuclide therapy. Over the last decades, several alpha-emitting radionuclides have entered and left research topics towards their clinical...
10.
Kiritsis C, Shegani A, Makrypidi K, Roupa I, Lazopoulos A, Panagiotopoulou A, et al.
Bioorg Med Chem
. 2022 Sep;
73:117012.
PMID: 36155319
Epidermal growth factor receptors (EGFR) of tyrosine kinase (TK) have shown high expression levels in most cancers and are considered a promising target for cancer diagnosis and therapy. Expanding the...