Hannah L Woodward
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Explore the profile of Hannah L Woodward including associated specialties, affiliations and a list of published articles.
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12
Citations
119
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Recent Articles
1.
Zhao Y, Mahy W, Willis N, Woodward H, Steadman D, Bayle E, et al.
ACS Chem Neurosci
. 2022 Jun;
13(13):2060-2077.
PMID: 35731924
The Wnt signaling suppressor Notum is a promising target for osteoporosis, Alzheimer's disease, and colorectal cancers. To develop novel Notum inhibitors, we used an X-ray crystallographic fragment screen with the...
2.
Willis N, Mahy W, Sipthorp J, Zhao Y, Woodward H, Atkinson B, et al.
J Med Chem
. 2022 May;
65(10):7212-7230.
PMID: 35536179
Notum is a carboxylesterase that suppresses Wnt signaling through deacylation of an essential palmitoleate group on Wnt proteins. There is a growing understanding of the role Notum plays in human...
3.
Bayle E, Svensson F, Atkinson B, Steadman D, Willis N, Woodward H, et al.
J Med Chem
. 2021 Mar;
64(8):4289-4311.
PMID: 33783220
Regulation of the Wnt signaling pathway is critically important for a number of cellular processes in both development and adult mammalian biology. This Perspective will provide a summary of current...
4.
Mahy W, Willis N, Zhao Y, Woodward H, Svensson F, Sipthorp J, et al.
J Med Chem
. 2020 Oct;
63(21):12942-12956.
PMID: 33124429
Carboxylesterase Notum is a negative regulator of the Wnt signaling pathway. There is an emerging understanding of the role Notum plays in disease, supporting the need to discover new small-molecule...
5.
Mahy W, Patel M, Steadman D, Woodward H, Atkinson B, Svensson F, et al.
J Med Chem
. 2020 Aug;
63(17):9464-9483.
PMID: 32787107
The Wnt family of proteins are secreted signaling proteins that play key roles in regulating cellular functions. Recently, carboxylesterase Notum was shown to act as a negative regulator of Wnt...
6.
Bellenie B, Cheung K, Varela A, Pierrat O, Collie G, Box G, et al.
J Med Chem
. 2020 Apr;
63(8):4047-4068.
PMID: 32275432
Deregulation of the transcriptional repressor BCL6 enables tumorigenesis of germinal center B-cells, and hence BCL6 has been proposed as a therapeutic target for the treatment of diffuse large B-cell lymphoma...
7.
Anderhub S, Mak G, Gurden M, Faisal A, Drosopoulos K, Walsh K, et al.
Mol Cancer Ther
. 2019 Oct;
18(10):1696-1707.
PMID: 31575759
BOS172722 (CCT289346) is a highly potent, selective, and orally bioavailable inhibitor of spindle assembly checkpoint kinase MPS1. BOS172722 treatment alone induces significant sensitization to death, particularly in highly proliferative triple-negative...
8.
Woodward H, Innocenti P, Cheung K, Hayes A, Roberts J, Henley A, et al.
J Med Chem
. 2018 Sep;
61(18):8226-8240.
PMID: 30199249
Monopolar spindle 1 (MPS1) occupies a central role in mitosis and is one of the main components of the spindle assembly checkpoint. The MPS1 kinase is an attractive cancer target,...
9.
Atkinson B, Woodward H, Sipthorp J, Fish P
Org Biomol Chem
. 2017 Nov;
15(46):9794-9799.
PMID: 29159344
A new efficient chiral synthesis of enantiopure arimoclomol (2) is reported from (R)-(-)-glycidyl nosylate (11) with complete retention of chiral integrity. Off-target pharmacology of arimoclomol (2) was evaluated against a...
10.
Faisal A, Mak G, Gurden M, Xavier C, Anderhub S, Innocenti P, et al.
Br J Cancer
. 2017 Mar;
116(9):1166-1176.
PMID: 28334731
Background: The main role of the cell cycle is to enable error-free DNA replication, chromosome segregation and cytokinesis. One of the best characterised checkpoint pathways is the spindle assembly checkpoint,...